einstein (São Paulo). 01/Mar/2010;8(1):29-33.

Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene

Vanessa Maria Caetano Soares, Braz Martorelli Filho, Luiz Roberto Araujo Fernandes, Umberto Gazi Lippi

DOI: 10.1590/s1679-45082010ao1227

ABSTRACT
Objective:
To study the effect of raloxifene on endometrial histopathology of menopausal women.
Methods:
Thirty-one patients under raloxifene treatment (60 mg/day) for a six-month period and submitted to diagnostic videohysteroscopy at the Climateric Outpatients Clinic, Department of Gynecology and Obstetrics, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, in the city of São Paulo, and at Hospital Guilherme Álvaro, in the city of Santos, from September 10th, 2003 to June 22nd, 2004, were analyzed. Guided endometrial biopsy was performed on all patients on the anterior wall, using a 3-mm or 5-mm biopsy forceps. A 3-mm or 5-mm hysteroscope was used with TV imaging by an endocamera. The results of the hysteroscopic tests were compared before and six months after the use of raloxifene.
Results:
The comparison between both biopsies was performed by means of the McNemar’s test (marginal homogeneity test), and showed a descriptive level of 0.001 that indicates difference between the estrogen effects assessed at different moments. The estrogen effect on the endometrial tissue did not increase in any of the 31 patients analyzed. Twenty-one patients (68%) showed smaller estrogen effect in the final evaluation.
Conclusions:
The study showed no evidence of endometrial stimulation of raloxifene and, in fact, many women presented less estrogen effect after its use.

Endometrial hysteroscopic and histological evaluation in menopausal women in continuous use of raloxifene

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