einstein (São Paulo). 19/Aug/2019;17(4):eAO4696.

Drug therapy problems for patients with tuberculosis and HIV/AIDS at a reference hospital

Natália Helena de Resende ORCID logo , Silvana Spíndola de Miranda ORCID logo , Maria das Graças Braga Ceccato ORCID logo , João Paulo Amaral Haddad ORCID logo , Adriano Max Moreira Reis ORCID logo , Dirce Inês da Silva ORCID logo , Wânia da Silva Carvalho ORCID logo

DOI: 10.31744/einstein_journal/2019AO4696



To determine the frequency of drug therapy problem in the treatment of patients with tuberculosis and HIV/AIDS.


Data were obtained through a cross-sectional study conducted between September 2015 and December 2016 at a reference hospital in infectious diseases in Belo Horizonte (MG), Brazil. Sociodemographic, clinical, behavioral and pharmacotherapeutic variables were evaluated through a semi-structured questionnaire. Drug-related problems of pharmaceutical care were classified using the Pharmacotherapy Workup method. Factors associated with indication, effectiveness, safety and compliance drug therapy problem were assessed through multiple logistic regression.


We evaluated 81 patients, and 80% presented at least one drug therapy problem, with indication and adherence drug therapy problem being the most frequent. The factors associated with drug therapy problem were age, marital status, new case, ethnicity, time of HIV diagnosis and time to treat tuberculosis.


The frequency of drug therapy problem in coinfected patients was high and the identification of the main drug therapy problem and associated factors may lead the multiprofessional health team to ensure the use of the most indicated, effective, safe and convenient medicines for the patients clinical condition. Tuberculosis and HIV/AIDS coinfected individuals aged over 40 years are more likely to have drug therapy problems during treatment; in that, the most frequente are those that signal toward need of medication for an untreated health condition and non-compliance to treatment. Thus, older patients, unmarried or married, who have treated tuberculosis before, with a shorter time to tuberculosis treatment and longer time to diagnose HIV/AIDS, should receive special attention and be better followed by a multiprofessional health team because they indicate a higher chance of presenting Problems related to the use of non-adherent drugs.

Drug therapy problems for patients with tuberculosis and HIV/AIDS at a reference hospital