einstein (São Paulo). 01/Dec/2012;10(4):466-72.

Comparative study of the results from conventional cervico-vaginal oncotic cytology and liquid-based cytology

Sueli Aparecida Batista Stabile, Dilson Henrique Ramos Evangelista, Valdely Helena Talamonte, Umberto Gazi Lippi, Reginaldo Guedes Coelho Lopes

DOI: 10.1590/S1679-45082012000400013

Objective:
To compare two oncotic cervical cytology techniques, the conventional and the liquid-based cytology, in low risk patients for uterine cervical cancer.
METHODS:
Comparative prospective study with 100 patients who came to their annual gynecological exam, and were submitted simultaneously to both techniques. We used the McNemar test, with a significance level of p<0.05 to compare the results obtained related to adequacy of the smear quality, descriptive diagnosis prevalence, guided biopsy confirmation and histology.
RESULTS:
Adequacy of the smear was similar for both methods. The quality with squamocolumnar junction in 93% of conventional cytology and in 84% of the liquid-based cytology had statistical significance. As for the diagnosis of atypical cells they were detected in 3% of conventional cytology and in 10% of liquidbased cytology (p=0.06). Atypical squamous cells of undetermined significance were the most prevalent abnormality. The liquid-based cytology performance was better when compared with colposcopy (guided biopsy), presenting sensitivity of 66.7% and specificity of 100%. There was no cytological and histological concordance for the conventional cytology.
CONCLUSIONS:
Liquid-based cytology had a better performance to diagnose atypical cells and the cytohistological concordance was higher than in the conventional cytology.

Comparative study of the results from conventional cervico-vaginal oncotic cytology and liquid-based cytology

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