einstein (São Paulo). 19/Apr/2018;16(1):eAO4143.

Association between hypovitaminosis D and frequency of pulmonary exacerbations in children and adolescents with cystic fibrosis

Renata Ongaratto, Katiana Murieli da Rosa, Juliana Cristina Eloi, Matias Epifanio, Paulo Marostica, Leonardo Araújo Pinto

DOI: 10.1590/S1679-45082018AO4143

Abstract

Objective

We evaluated the association between vitamin D levels and nutritional status, pulmonary function and pulmonary exacerbations in children and adolescents with cystic fibrosis.

Methods

25-hydroxyvitamin D (25(OH)D) levels of 37 children and adolescents were retrospectively evaluated. Pulmonary function, body mass index, height for age, and pulmonary exacerbations episodes were associated with vitamin D levels divided into two groups: sufficient (≥30ng/mL) and hypovitaminosis (<30ng/mL).

Results

Hypovitaminosis D (25(OH)D <30ng/mL) was observed in 54% of subjects. The mean level of 25(OH)D was 30.53±12.14ng/mL. Pulmonary function and nutritional status were not associated with vitamin D levels. Pulmonary exacerbations over a 2-year period (p=0.007) and the period from measurement up to the end of the follow-up period (p=0.002) were significantly associated with vitamin D levels.

Conclusion

Hypovitaminosis D was associated with higher rates of pulmonary exacerbations in this sample of children and adolescents with cystic fibrosis. Hypovitaminosis D should be further studied as a marker of disease severity in cystic fibrosis. Further prospective and randomized studies are necessary to investigate causality of this association.

Association between hypovitaminosis D and frequency of pulmonary exacerbations in children and adolescents with cystic fibrosis

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