Highlights ■ Higher miR-23a levels in patients with premature ovarian insufficiency vs. normovulatory women. ■ Lower miR-146a levels in patients with premature ovarian insufficiency vs. normovulatory women. ■ Novel biomarkers for early diagnosis and monitoring of premature ovarian insufficiency. ■ Potential biomarkers to therapeutic targets for premature ovarian insufficiency. ABSTRACT Objective: This study aimed to analyze the expression profiles of miR-23a and miR-146a in women with premature ovarian insufficiency and to evaluate their value as biomarkers of the disease for […]

Highlights ■ First study to investigate associations between cognitive performance and brain magnetic resonance imaging parameters in an older Brazilian population. ■ Uses advanced magnetic resonance imaging diffusion tensor imaging and automated analysis to quantify brain changes. ■ Validates findings through comparison with data from a large UK-based cohort. ■ Focuses on region-specific assessments, such as the superior longitudinal fasciculus and other key brain areas related to cognition. ■ Demonstrates significant correlation between 3MS and MMSE cognitive scores and diffusion […]

 Highlights ■ The average total QAS-Tele score was 4.71±0.54 out of 5. ■ Higher satisfaction was reported by older adults in the younger age range. ■ Higher satisfaction was reported by individuals currently working. ■ Higher satisfaction was reported by individuals with a higher number of comorbidities. ABSTRACT Objective: This retrospective observational study analyzed satisfaction with a telehealth service in older individuals living in a metropolitan city in Brazil. Methods: Sociodemographic, clinical, and telehealth service details (number of clinical appointments […]

Highlights ■ Net Promoter Scores of 85 and 91 among patients and physicians, respectively, over three years. ■ A total of 99.3% of patients were satisfied with the teleconsultation. ■ A total of 98.5% of physicians reported overall satisfaction with the program. ■ Surveys reflect excellence in telemedicine expert consultation. ABSTRACT Objective: Telemedicine via teleconsultations enhances access to specialized care. However, the degree of satisfaction among patients and providers with this method remains unclear. This study assessed patient and on-site […]

Highlights ■ Public hospitals in Brazil performed 37,741 hallux valgus surgery procedures between January 2008 and October 2024. ■ The study population consisted of 79.7% females, with the most common age group being 40-69 years (67.7%). The mean length of stay was 1.7 days. ■ The mean cost per patient was US$ 141.53. ■ The overall mortality count was nine, corresponding to a death rate of 0.024%. ABSTRACT Objective: This study aimed to describe patient profiles and analyze costs, hospital […]

Highlights ■ Previous studies have correlated inflammation with complications after percutaneous coronary intervention. ■ In patients with stable coronary disease, percutaneous coronary intervention leads to elevated inflammatory biomarker levels. ■ The inflammatory response is significantly correlated with myocardial injury. ABSTRACT Introduction: In acute coronary syndrome, the release of inflammatory and myocardial injury biomarkers after percutaneous coronary intervention is associated with poor prognosis. However, little is known about the association between these biomarkers in patients with stable disease. Objective: We aimed […]

Highlights ■ Nursing workload is high with patients undergoing extracorporeal membrane oxygenation. ■ The initial 24 hours of extracorporeal membrane oxygenation have the highest workload, quantified using the Nursing Activities Score. ■ Presence of COVID-19 and delayed extracorporeal membrane oxygenation initiation increase the workload in the initial 24 hours of extracorporeal membrane oxygenation. ■ Extracorporeal membrane oxygenation care demands adjustments in the nurse-to-patient ratio in the intensive care unit. ABSTRACT Objective: To identify the factors associated with nursing workload with […]

Highlights ■ Understanding the composition of urinary calculi is essential for guiding long-term treatment strategies. ■ This is the first study to correlate clinical data with crystallographic analysis of urinary stones. ■ Clinical criteria allow for a high likelihood of accurately identifying stone composition. ■ Clinical findings can serve as valuable tools for guiding treatment decisions. ABSTRACT Objective: This study aimed to evaluate whether clinical, laboratory, and radiological data could effectively identify struvite stones without the need for crystallographic analysis. […]

Highlights ■ A total of 58.1% of the patients died during a mean follow-up period of approximately 5.2 years. ■ Cardiovascular diseases are the main cause of death in these patients. ■ Men had a higher likelihood of death from all causes than women. ■ No difference was found between the sexes in relation to the different causes of death. ABSTRACT Objective: To compare mortality rates between sexes in a cohort of patients with intermittent claudication residing in a metropolitan […]

Highlight ■ This method enables surgeons to visually identify the lesion pathway without intraoperative imaging, enhancing precision and workflow. ■ A practical, cost-effective alternative to high-end technologies such as electromagnetic navigation bronchoscopy and hybrid operating rooms. ■ Metallic wires offer excellent intraoperative visibility on the lung surface, supporting their clinical utility. ■ All nonpalpable nodules were successfully resected, with no complications related to the preoperative localization procedure. ■ CT-guided preoperative localization of nonpalpable pulmonary lesions using a purpose-built device demonstrates […]