Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]

Highlights ■ In multifocal papillary thyroid microcarcinomas: ■ The total tumor diameter was not associated with aggressiveness or initial evolution. ■ Other factors are associated with disease outcomes. ■ The number of metastatic lymph nodes is an independent predictor of American Joint Committee on Cancer stage. ABSTRACT Objective: To evaluate whether the total tumor diameter (sum of the largest diameters of all foci) predicts tumor aggressiveness at initial presentation and treatment response at 1-year follow-up in patients with multifocal papillary […]

Highlights ■ Two gene groups with contrasting expression profiles were identified. ■ The ATP1B3 and SLCOB3 gene profiles classified patients with 90% accuracy. ■ The ATP1B3 and SLCOB3 gene signature is a potential predictor of treatment response. ABSTRACT Introduction: Cervical cancer is the fourth most common cancer in women worldwide. Resistance to chemoradiotherapy in cervical cancer has been widely associated with membrane transport-related genes, particularly those encoding efflux transport proteins, such as the ATP-binding cassette family members (including P-glycoprotein), which […]

Highlights ■ Performance was <70% in 10 of the 33 items. ■ Lowest performance domains were Oncologic Pain and Opioid Side Effects. ■ Residents in clinical specialties outperformed those in surgical or mixed specialties. ■ Residents with ≥3 years of training outperformed those on their first 2 years. ABSTRACT Objective: To translate, cross-culturally adapt, and validate the Palliative Care Knowledge Questionnaire for PEACE (PEACE-Q) in Brazilian Portuguese. Methods: This study followed five steps: translation, back-translation, cultural adaptation, pre-test, and test-retest. […]

Highlights ■ MMP-1, MMP-2, and MMP-3 are upregulated in endometriotic lesions. ■ The study findings suggest a senescence-associted secretory phenotype in endometriosis. ■ The study findings support targeting senescence pathways in endometriosis. ABSTRACT Objective: To investigate the roles of cellular senescence and dysfunctional extracellular matrix metalloproteinases (MMPs) in perpetuating chronic inflammation and facilitating the establishment of endometriotic lesions. By analyzing the MMP activity in the endometrial tissue and peritoneal fluid, we aimed to obtain novel insights into the molecular mechanisms […]

Highlights ■ Logistical factors were not responsible for most organ rejections in the single national waiting list. ■ Refusal information was operator dependent, as the reason for refusal was generic in most cases. ■ It is possible to increase the use of organs offered to the National Transplant Center by converting more offers into transplants performed through a more detailed study of the reasons for refusal. ABSTRACT Objective: To investigate the outcomes and reasons for the refusal of organs offered […]

Highlights ■ Aussie Current decreases immediate pain intensity. ■ Both carrier frequencies of Aussie Current were efficient in decreasing pain. ■ There are no ideal parameters for using the Aussie Current to relieve pain in individuals with chronic lower back pain. ABSTRACT Objective: To analyze the immediate analgesic effects of Aussie Current on chronic low back pain using different parameters. Methods: A total of 105 patients (aged 18-80 years, of both sexes, with chronic low back pain) were randomized into […]

Highlights ■ The quantity of dental procedures in prisons differs across Brazilian regions. ■ Prisoners’ access to dental procedures was limited even prior to the pandemic. ■ Preventive, urgent, and dental extraction procedures exhibited increases. ■ Restorative and periodontic procedures did not exhibit statistically significant changes. ABSTRACT Objective: This study compared the productivity of prison oral health teams during the COVID-19 crisis (2020–2022) with the previous three-year period (2017–2019) to identify the number and type of dental procedures performed. Methods: […]

Highlights ■ Assessing how vascular access devices affect quality of life is essential to effectively manage chemotherapy patients. ■ The translation and validation of the QoLVAD questionnaire demonstrated that the Brazilian Portuguese version can be applied to the Brazilian population. ABSTRACT Background: The use of long-term devices for chemotherapy in neoplastic diseases is very common. The CAVA trial was an extensive study that prospectively evaluated more than 1000 patients undergoing chemotherapy and randomly allocated them to three groups based on […]

Highlights ■ Ensuring quality education, providing vocational training, and promoting communication technology, technical, and scientific programs are goals set by the United Nations to enhance learning opportunities for all. ■ Critical thinking, fostered through theoretical and practical activities, is essential for building relevant skills, including literacy and numeracy. ■ The Scientists of Tomorrow/Cientistas do Amanhã project is a reproducible initiative that can be implemented in other research centers and schools. ABSTRACT The Scientists of Tomorrow project is a partnership between […]