Highlights Klotho controls cellular pathways and is a key factor in senescence and longevity. FGF-23 regulates phosphorus and vitamin D metabolism in a Klotho-dependent manner. Bone formation in Klotho-deficient mice decreased similar to that in aged humans. Renal function and lumbar spine bone mineral density were related to Klotho and FGF-23, respectively. ABSTRACT Objective: To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals. Methods: A total of 55 individuals […]

Highlights From the One Health approach, empathy represents the initial movement towards achieving planet harmony. The more emotions we attribute to animals, the more we develop pro-conservation behaviors. AES-Brazil may serve as a tool for reflection and monitoring interventions in human-animal relationships. ABSTRACT Objective: To design and validate a Brazilian version of the Animal Empathy Scale, based on the existing Portuguese version. Methods: Content validity assessment was performed by expert judges, and the adapted scale was administered to a sample […]

Highlights Small-litter promotes greater body weight gain, adiposity, and metabolic abnormalities in adulthood. Small-litter -adult obese rats showed augmented hypothalamic expression of GLP1-R and Lep-R. Swimming training throughout life avoids obesity and metabolic disorders in small-litter-adult rats. Regular exercise can normalize GLP1-R and Lep-R hypothalamic expressions in small-litter-adult rats. ABSTRACT Objective: Glucagon-like peptide-1 (GLP1) and leptin (Lep) are afferent signals that regulate energy metabolism. Lactational hypernutrition results in hyperphagia and adiposity in adult life, and these events can be prevented […]

Highlights Excess moisture can lead to maceration and contribute to skin breakdown. Superficial pressure ulcers were the most common and can be easily prevented. Healthcare professionals should be aware of PU risk factors, evaluate skin daily, and offer prevention. ABSTRACT Objective: To estimate the point prevalence of and risk factors associated with the development of pressure ulcers at a university hospital in Brazil. Methods: This study was conducted on 196 participants using a structured questionnaire, physical examination of the skin, […]

Highlights A  single-center study evaluated the prevalence and risk factors for Burnout syndrome in intensive care unit teams. The study revealed a high prevalence of Burnout syndrome in at least one dimension. Factors such as profession and having two or more jobs were associated with severe burnout symptoms. The study highlighted the need for interventions and support to address burnout among intensive care unit teams. ABSTRACT Objective: To evaluate the prevalence of burnout among the intensive care unit team of […]

Highlights Only 20% of the medical residency programs have laparoscopic teaching. Preceptors of the residency programs have advanced experience. Most programs have no plan to set up a training center. Resideny programs are concentrated in the Southeast region and in capitals. ABSTRACT Objective: To characterize laparoscopy teaching in Medical Residency Programs in Gynecology and Obstetrics in Brazil, and to evaluate preceptors’ characteristics in laparoscopy programs and map laparoscopic training practice scenarios. Methods: This descriptive cross-sectional study evaluated questionnaire responses from […]

Highlights Positive airway pressure may improve the severity of asthma exacerbation. A high-flow nasal cannula can improve respiratory physiotherapy outcomes. Positive airway pressure is indicated for moderate asthma exacerbation. Bilevel positive airway pressure and high-flow nasal cannula use may improve the pulmonary function. ABSTRACT Objective: To evaluate and compare the efficacy of high-flow nasal cannula treatment and that of bilevel positive airway pressure treatment as respiratory physiotherapy interventions for pediatric patients who are hospitalized because of asthma exacerbation. Methods: During […]

Highlights This study contributes data on the pharmacogenomics of acetylsalicylic acid. Brazilian data contribute to reducing the lack of diversity in genetic studies examining unrepresented groups. The genetic variants evaluated were not associated with gastrointestinal bleeding. ABSTRACT Objective: The use of acetylsalicylic acid, even in low doses, may be associated with the onset of upper gastrointestinal bleeding as an idiosyncratic response. Considering the role of the genetic background in inter-individual responses to pharmacotherapy, we aimed to investigate the role of […]

Highlights Multicancer early detection panels are novel assays that allow screening for dozens of cancers using a single blood sample. Data on the optimal workflow for ordering, interpreting, and managing subsequent evaluations of multi-cancer early detection results are lacking. Primary care providers expressed concerns about the cost and management of subsequent evaluations for a positive multicancer early detection test. ABSTRACT Objective Multicancer early detection panels have recently become available to patients with healthcare provider prescriptions and available funds. These tests […]

Highlights Acute respiratory distress syndrome is a severe presentation of COVID-19 without effective treatment despite intensive research. Inhaled nitric oxide is a vasodilator that has been studied in patients with acute respiratory distress syndrome COVID-19 yielding contradictory results. The use of inhaled nitric oxide rescue therapy in critically ill patients with COVID-19 experiencing moderate-to-severe acute respiratory distress syndrome was significantly associated with an improvement in oxygenation parameters with no difference in mortality. ABSTRACT Objective: To evaluate the responsiveness of COVID-19 […]