Highlights First study to investigate the rs10835638 variant in Brazilian women with endometriosis. The homozygous TT genotype was very rare among Brazilian women. G۪۪enotype frequencies did not differ between endometriosis and Control Groups. The T allele was more common in minimal/mild endometriosis subgroups than in the Control Group. ABSTRACT Objective: The follicle-stimulating hormone subunit beta gene rs10835638 variant (c.-211G>T) may have detrimental effects on fertility and protective effects against endometriosis. A casecontrol analysis was performed, aiming to investigate the possible […]

Highlights ■ AKT signaling sustains the immune evasion mechanisms in acute myeloid leukemia. ■ AKT inhibition increases the susceptibility of acute myeloid leukemia cells to natural Killer-mediated apoptosis. ■ Partial blockage of AKT signaling promotes the suppression of PDL1 and overexpression of pro-apoptotic genes. ABSTRACT Objective To determine the role of the AKT pathway in the regulating of natural Killer-induced apoptosis of acute myeloid leukemia cells and to characterize the associated molecular mechanisms. Methods BALB/c nude mice were injected with […]

Highlights All kinds of personal protective equipment training decreased the odds of COVID-19 infection among healthcare professionals.۪ We found lower odds of infection in participants who underwent face-to-face simulation-based training.۪ Simulation-based personal protective equipment training is feasible, effective, and safe, even during the COVID-19 pandemic. ABSTRACT Objective To describe the personal protective equipment training strategies during the beginning of the pandemic and to investigate the association between training and COVID-19 infection among healthcare workers. Methods This cross-sectional study conducted between […]

Highlights Seventy-four (33.18%) municipalities in the state of Paraíba registered live births with microcephaly. The highest proportion of cases (23.03%) was concentrated in the capital, João Pessoa. Number of inhabitants, number of cases of Zika virus, water supply, and average household income were associated with a higher proportion of new cases. ABSTRACT Objective To analyze the relationship between microcephaly and social inequality indicators in the state of Paraíba during the biennium January 2015 and December 2016. Methods Ecological study with […]

ABSTRACT Objective To evaluate whether there is a significant difference in somatostatin analog uptake in meningiomas treated or not with radiation therapy. Methods A cross-sectional study was performed comparing measurements of somatostatin analog (68Ga-DOTATATE) uptake in two independent groups of ten patients each – one consisting of patients with meningiomas previously treated with radiation therapy and another comprising patients who had never been submitted to radiation therapy. All patients underwent PET/CT and MRI scans in an interval shorter than 24 […]