Highlights ■ The rs2814778 C allele is linked to severe/critical COVID-19. ■ The association is independent of major clinical risk factors. ■ The Duffy “null” phenotype may promote lung inflammation. ■ rs12075 and rs4073 showed no association with COVID-19 severity. ABSTRACT Objective: This study aimed to analyze the possible association between rs2814778, rs12075 (ACKR1 gene), and rs4073 (CXCL8 gene) single nucleotide variants and COVID-19 severity. Methods: This cross-sectional study included 319 COVID-19 diagnosed patients at two hospitals in Paraná, Brazil […]

Highlights First study to investigate the rs10835638 variant in Brazilian women with endometriosis. The homozygous TT genotype was very rare among Brazilian women. G۪۪enotype frequencies did not differ between endometriosis and Control Groups. The T allele was more common in minimal/mild endometriosis subgroups than in the Control Group. ABSTRACT Objective: The follicle-stimulating hormone subunit beta gene rs10835638 variant (c.-211G>T) may have detrimental effects on fertility and protective effects against endometriosis. A casecontrol analysis was performed, aiming to investigate the possible […]