08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
einstein (São Paulo). 08/Aug/2025;23:eAO1601.
View Article08/Aug/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
DOI: 10.31744/einstein_journal/2025AO1601
Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]
Keywords: Biomarkers; Disease progression; Disease-free survival; Health strategies; Lipid metabolism; Lymph nodes; Prognosis; Prostatic neoplasms
22/Apr/2025
Socioeconomic inequities in prostate cancer care: private versus public treatment settings pose a significant impact on overall survival
einstein (São Paulo). 22/Apr/2025;23:eAO0851.
View Article22/Apr/2025
Socioeconomic inequities in prostate cancer care: private versus public treatment settings pose a significant impact on overall survival
DOI: 10.31744/einstein_journal/2025AO0851
Highlights ■ Men with metastatic prostate cancer in the public system have access to fewer treatment lines. ■ Survival in the public system was 3 years shorter than that in the private setting (78 versus 115 months). ABSTRACT Objective: To evaluate the impact of assistance from public and private health systems on the overall survival of patients with metastatic prostate cancer. Methods: A total of 213 patients with metastatic prostate cancer treated at the A.C. Camargo Cancer Center, either in […]
Keywords: Brazil; Health Services; Health systems; Neoplasm metastasis; Private sector; Prostatic neoplasms; Public sector; Race factors; Social determinants of health; Survival analysis
31/Oct/2024
Irreversible electroporation for prostate cancer: another promising focal therapy
DOI: 10.31744/einstein_journal/2024RC0779
ABSTRACT Radical treatment for prostate cancer is associated with significant morbidity. Percutaneous image-guided irreversible electroporation is a non-thermal ablative technique that has emerged as a valuable option. This study describes the case of a patient with prostate cancer who was successfully treated using irreversible electroporation. We report the case of a 72-year-old male patient who presented with elevated PSA (4.0ng/mL) during routine testing. Multiparametric magnetic resonance imaging of the prostate revealed a 0.8 cm lesion in the posterolateral aspect of […]
Keywords: Ablation techniques; interventional; Irreversible electroporation therapy; Multiparametric magnetic resonance imaging; Prostatic neoplasms; Radiology
11/Oct/2023
Epidemiological profile of COVID-19 in patients with prostate cancer undergoing androgen deprivation therapy at a Brazilian Cancer Center
einstein (São Paulo). 11/Oct/2023;21:eAO0273.
View Article11/Oct/2023
Epidemiological profile of COVID-19 in patients with prostate cancer undergoing androgen deprivation therapy at a Brazilian Cancer Center
DOI: 10.31744/einstein_journal/2023AO0273
Highlights We were unable to prove an association between the use of androgen deprivation therapy and a reduction in factors associated with worse clinical outcomes. Most of the data presented show a tendency to favor the outcomes of patients who do not undergo androgen deprivation therapy, which can be explained by the fact that, in general, their clinical conditions are better and their performance status scores are lower than those of patients who undergo androgen deprivation therapy. ABSTRACT Objective: To […]
Keywords: Androgens; Antineoplastic agents; Coronavirus infections; COVID-19; hormonal; Prostatic neoplasms; SARS-CoV-2
21/Nov/2022
Radical prostatectomies for treatment of prostate cancer: trends in a ten-year period in public health services in the city of São Paulo, Brazil
einstein (São Paulo). 21/Nov/2022;20:eAO0049.
View Article21/Nov/2022
Radical prostatectomies for treatment of prostate cancer: trends in a ten-year period in public health services in the city of São Paulo, Brazil
DOI: 10.31744/einstein_journal/2022AO0049
ABSTRACT Objective To analyze the characteristics of public health services related to radical prostatectomy, according to hospital volume of surgeries and stratified as academic and non-academic centers. Methods An ecological study was conducted using a database available in TabNet platform of the Unified Health System Department of Informatics. Number of surgeries, length of hospital stay, length of stay in intensive care unit, in-hospital mortality rate, and cost of hospitalization were evaluated. The hospitals were divided into three subgroups according to […]
Keywords: Prostatectomy; Prostatic neoplasms; Public health
21/Nov/2022
Prostate imaging features on magnetic resonance imaging of young patients
DOI: 10.31744/einstein_journal/2022AO0024
ABSTRACT Objective To identify magnetic resonance imaging findings of the prostate in young adults, including symptomatic and asymptomatic patients. The aim of this study is to evaluate the main aspects of prostate imaging in young patients. Methods A total of 102 patients under 40 years of age, who underwent prostate magnetic resonance imaging between January 2016 and January 2019, were included in this study. The patients were divided into two groups: symptomatic for prostatitis (Group 1) and asymptomatic (Group 2). […]
Keywords: Magnetic resonance imaging; Prostate; Prostatic neoplasms
06/May/2022
Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer
DOI: 10.31744/einstein_journal/2022AO6599
ABSTRACT Objective To evaluate the predictive value of positron emission computed tomography or magnetic resonance (PET-CT and PET-MRI) using gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA) in lymph node involvement in prostate cancer. Methods A retrospective study comprising 91 patients diagnosed with prostate cancer between 2016 to 2020, who underwent 68Ga-PSMA PET-CT or PET-MRI for staging before prostatectomy. The patients were divided into Group 1, with 65 patients with satisfactory pathological lymph node analysis, and Group 2, with 91 patients representing the […]
Keywords: Data accuracy; Gallium; Lymph nodes; Positron emission tomography computed tomography; Prostate-specific antigen; Prostatectomy; Prostatic neoplasms
22/Nov/2021
Prostate cancer awareness in the city of São Paulo
DOI: 10.31744/einstein_journal/2021AO6325
ABSTRACT Objective: To evaluate awareness of prostate cancer in the population of the city of São Paulo. Methods: A total of 392 adults were randomly interviewed on public spaces in the city of São Paulo, and answered a questionnaire that addressed demographic questions and specific knowledge about the prostate cancer. A score was used to assess awareness of cancer in general, and of prostate cancer, considering satisfactory knowledge a score of 6 points. Results: The mean age was 36.9 years […]
Keywords: Knowledge; Mass screening; Prostatic neoplasms; Surveys and questionnaires
11/Jul/2019
Comparative study between monoexponential and biexponential diffusion weighted imaging sequences in multiparametric prostate magnetic resonance imaging
DOI: 10.31744/einstein_journal/2019AO4615
ABSTRACT Objective: To compare qualitatively and quantitatively, in terms of image quality, a new biexponential diffusion sequence protocol with the standard monoexponential diffusion protocol on multiparametric prostate magnetic resonance imaging. Methods: This study had a prospective data collection and cross-sectional analysis. Between August and November 2017, a total of 70 patients who underwent multiparametric prostate magnetic resonance imaging due to clinical suspicion of prostatic neoplasia were recruited. The images obtained were evaluated by two independent readers regarding subjective/qualitative criteria (six […]
Keywords: Biexponencial diffusion; Diffusion magnetic resonance imaging; Intravoxel incoherent motion; Magnetic resonance imaging; Monoexponencial diffusion; Multiparametric prostate magnetic resonance imaging; Prostatic neoplasms
01/Jan/2017
PET/MRI: a novel hybrid imaging technique. Major clinical indications and preliminary experience in Brazil
DOI: 10.1590/S1679-45082017MD3793
ABSTRACT In recent years, medical imaging with hybrid techniques has widely accepted and employed in clinical routine. PET/MRI offers significant advantages, including excellent contrast and resolution and reduced ionizing radiation, as compared to well-established PET/CT. Therefore, PET/MRI is a promising modality for oncologic imaging of some regions, such as brain, head and neck, liver and pelvis. This article set out to analyze clinical conditions that could benefit from PET/MRI imaging based on our caseload. The potential of PET/MRI to become […]
Keywords: Magnetic resonance imaging/methods; Neuroimaging; Pelvic neoplasms; Positron-emission tomography/methods; Prostatic neoplasms; Tomography, x-ray computed/methods