02/Jul/2025
Use of propensity score matching to reduce bias in economic evaluations in the context of Brazilian liver transplantation
DOI: 10.31744/einstein_journal/2025AO1329
Highlights ■ Matching methodologies may reduce bias in economic evaluations. ■ Liver transplantation within the Proadi-SUS context has an incremental cost-effectiveness ratio below the Health Technology Incorporation in the Brazilian Health System threshold. ■ The patients who received transplant had a median survival of 10.1 years after list enrollment. ■ The mean cost per transplanted patient was US$ PPP 162,821.96. ABSTRACT Objective: To estimate the incremental cost and survival of patients on the liver transplantation waiting list who were referred […]
Keywords: Brazil; Cost-benefit analysis; Hospital costs; Liver transplantation; Propensity score; Survival rate; Unified Health System; Waiting lists
28/Mar/2025
Impact of liver transplantation on the quality of life of a cohort of high-risk recipients
DOI: 10.31744/einstein_journal/2025AO0565
Highlights ■ Liver transplantation improves health-related quality of life in patients with cirrhosis and high MELD scores. ■ Significant health-related quality of life improvements occur within three months of transplantation. ■ Multidisciplinary care programs enhance post-iver transplantation physical and mental recovery. ■ Sustained health-related quality of life gains highlight the long-term benefits of liver transplantation. ABSTRACT Objective: To assess the effects of liver transplantation on the health-related quality of life of patients with cirrhosis on the waiting list for transplantation. […]
Keywords: Alcoholism; Health status; Liver cirrhosis; Liver transplantation; Morbidity; Quality of life; Surveys and questionnaires; Waiting list
25/Sep/2024
Cost-effectiveness of radiofrequency ablation versus percutaneous ethanol injection for early hepatocellular carcinoma in a resource-poor setting: a randomized trial
einstein (São Paulo). 25/Sep/2024;22:eGS0683.
View Article25/Sep/2024
Cost-effectiveness of radiofrequency ablation versus percutaneous ethanol injection for early hepatocellular carcinoma in a resource-poor setting: a randomized trial
DOI: 10.31744/einstein_journal/2024GS0683
Highlights Radiofrequency ablation and percutaneous ethanol injection are neoadjuvant hepatocellular carcinoma treatment methods. Radiofrequency ablation achieves a higher complete response rate (96.3% versus 60.0%, p=0.001). Total cost analyses showed radiofrequency ablation as a more expensive method (p<0.001). The incremental cost-effectiveness ratio was US$ -2674.59 with an advantage for radiofrequency ablation. Incremental effectiveness (34.2%) was in favor of radiofrequency ablation versus percutaneous ethanol injection. ABSTRACT Objective: This study assessed the cost-effectiveness of radiofrequency ablation compared with percutaneous ethanol injection in patients […]
Keywords: Ablation techniques; Cost-effectiveness evaluation; Liver neoplasms; Liver transplantation; Radiology, Interventional
06/May/2024
Oral candidiasis in liver transplant patients: species identification and antifungal susceptibility profile
einstein (São Paulo). 06/May/2024;22:eAO0138.
View Article06/May/2024
Oral candidiasis in liver transplant patients: species identification and antifungal susceptibility profile
DOI: 10.31744/einstein_journal/2024AO0138
Highlights Fifteen liver transplant patients presented with oral candidiasis. The two prevalent types of candidiasis were atrophic and pseudomembranous. Candida albicans and Candida glabrata were the most prevalent species. Most isolates were susceptible to antifungal agents. ABSTRACT Objective: This study aimed to verify oral candidiasis, identify the causative species, and investigate the antifungal susceptibility of yeasts isolated from liver transplant patients. Methods: A descriptive analysis of 97 patients who underwent liver transplantation was conducted at a hospital. Two clinical examinations […]
Keywords: Antifungal agents; Candida; Candidiasis; Candidiasis, oral; Liver transplantation
23/May/2023
Combined liver-kidney transplant in polycystic diseases: a case report
DOI: 10.31744/einstein_journal/2023RC0282
ABSTRACT Polycystic liver disease, a hereditary pathology, usually manifests as autosomal dominant polycystic kidney disease. The many cysts in the liver cause massive hepatomegaly, majorly affecting the patient’s quality of life. In cases of refractory symptoms, liver transplantation is the only treatment choice. A 43-year-old woman was followed up as a hepatology outpatient in August 2020, with a progressive increase in abdominal volume, lower limb edema, and cachexia. The patient was diagnosed with polycystic renal and liver disease with massive […]
Keywords: Hepatomegaly; Kidney transplantation; Liver diseases; Liver failure; Liver transplantation; Polycystic kidney, autosomal dominant
24/May/2022
Bolus versus continuous insulin infusion in immediate postoperative blood glucose control in liver transplantation: pragmatic clinical trial
einstein (São Paulo). 24/May/2022;20:eAO6959.
View Article24/May/2022
Bolus versus continuous insulin infusion in immediate postoperative blood glucose control in liver transplantation: pragmatic clinical trial
DOI: 10.31744/einstein_journal/2022AO6959
ABSTRACT Objective: To analyze the effectiveness and safety of two insulin therapy techniques (continuous and intermittent infusion) in the blood glucose control of people who have undergone liver transplantation, in the immediate postoperative period. Methods: The study was a prospective, open, pragmatic clinical trial with 42 participants, divided into two groups of 21 patients each, in the immediate postoperative period following liver transplantation. Participants in the Experimental Group and Control Group received continuous infusion and bolus insulin, respectively, starting at […]
Keywords: Glycemic control; Insulin infusion systems; Liver transplantation; Postoperative period
04/Mar/2022
What is the role of heat shock protein in abdominal organ transplantation?
DOI: 10.31744/einstein_journal/2022RB6181
ABSTRACT Ischemia-reperfusion injury is a pathophysiological event occuring after abdominal organ transplantation, and has a significant influence on prognosis and survival of the graft. It is involved in delaying the primary function or non-functioning of the graft. The objective of this study was to provide information on heat shock protein mechanisms in ischemia-reperfusion injuries in abdominal organ transplantations, and to indicate the possible factors involved that may influence the graft outcome. Several classes of heat shock proteins are part of […]
Keywords: Heat-shock proteins; Kidney transplantation; Liver transplantation; Organ transplantation; Reperfusion injury
22/Nov/2021
Disposal of donor livers in Brazil: how to optimize their utilization rate in transplants?
DOI: 10.31744/einstein_journal/2021AO6770
ABSTRACT Objective: To understand the professionals´ perception of the use of deceased donor liver for transplantation, the reasons to decline them, and propose strategies to increase their use safely. Methods: This is a cross-sectional, descriptive qualitative-quantitative study. Professionals working with liver transplantation answered a self-administered, structured, and electronic questionnaire comprising 17 questions distributed into four sessions (demographic factors, perception of use of organs, reasons for disposal, and measures to favor their usage). Results: A total of 42 professionals participated in […]
Keywords: Liver transplantation; Organ preservation; Perfusion/methods; Tissue and organ procurement
06/Apr/2018
Assessment and enrolment process for liver transplantation: nursing management through quality indicators
DOI: 10.1590/S1679-45082018AO3975
ABSTRACT Objective To establish, measure and analyze quality indicators in the evaluation and enrolment process of patients in a liver transplant program. Methods A quantitative and non-experimental research, with data collected from the database of a liver transplant program, from September 2012 to September 2014. Descriptive statistics were used to analyze the quality indicators identified. Results We analyzed 1,311 visits in the transplant outpatient clinic, most males (66.7%), white (65.1%), mean age of 53 (±12.5) years, from the Southeastern Region […]
Keywords: Disease management; health care; Liver transplantation; Patient selection; Quality indicators; Quality of Health Care
04/Apr/2017
The role of thromboelastometry in the assessment and treatment of coagulopathy in liver transplant patients
DOI: 10.1590/S1679-45082017MD3903
ABSTRACT Perioperative monitoring of coagulation is vital to assess bleeding risks, diagnose deficiencies associated with hemorrhage, and guide hemostatic therapy in major surgical procedures, such as liver transplantation. Routine static tests demand long turnaround time and do not assess platelet function; they are determined on plasma at a standard temperature of 37°C; hence these tests are ill-suited for intraoperative use. In contrast, methods which evaluate the viscoelastic properties of whole blood, such as thromboelastogram and rotational thromboelastometry, provide rapid qualitative […]
Keywords: Blood coagulation; Blood transfusion; Hemorrhage; Liver transplantation; Thrombelastography; Transplantation