2 results

Effect of maternal diabetes on female offspring

Juliana de Oliveira Martins, Maurício Isaac Panício, Marcos Paulo Suehiro Dantas, Guiomar Nascimento Gomes

DOI: 10.1590/S1679-45082014AO3200

ObjectiveTo evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the […]

Predictive performance of 12 equations for estimating glomerular filtration rate in severely obese patients

Ary Serpa Neto, Felipe Martin Bianco Rossi, Rodrigo Dal Moro Amarante, Marçal Rossi

DOI: 10.1590/s1679-45082011ao1922

ABSTRACTObjective:Considering that the Cockcroft-Gault formula and the equation of diet modification in renal disease are amply used in clinical practice to estimate the glomerular filtration rate, although they seem to have low accuracy in obese patients, the present study intends to evaluate the predictive performance of 12 equations used to estimate the glomerular filtration rate in obese patients.Methods:This is a cross-sectional retrospective study, conducted between 2007 and 2008 and carried out at a university, of 140 patients with severe obesity […]