All publications of “Guiomar Nascimento Gomes”

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Effect of maternal diabetes on female offspring

Juliana de Oliveira Martins, Maurício Isaac Panício, Marcos Paulo Suehiro Dantas, Guiomar Nascimento Gomes

DOI: 10.1590/S1679-45082014AO3200

ObjectiveTo evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the […]