Highlights ■ This large real-world study analyzed blood cholesterol trends over a 15-year period in São Paulo, Brazil. ■ Mean total and LDL-C decreased significantly across all groups. ■ A higher proportion of patients achieved recommended  LDL-C target levels. ■ The observed trends may reflect improvements in cardiovascular prevention strategies and treatment efficacy. ABSTRACT Objective: This study aimed to evaluate monthly trends in low-density lipoprotein cholesterol (LDL-C) levels in the examined population. Methods: Monthly trends in LDL-C levels from 2009 […]