3 results

Relationship between sleep deprivation and anxiety: experimental research perspective

Gabriel Natan Pires, Sergio Tufik, Monica Levy Andersen

DOI: 10.1590/S1679-45082012000400022

Sleep deprivation is a condition that is more and more observed in modern society bringing various neurobehavioral effects, being anxious states one of the main problems. Many studies have successfully demonstrated the relationship between sleep deprivation and anxiety in clinical research. As to basic experimentation, various models have been efficiently used in order to evaluate an anxious behavior. However, the same efficacy is not found on basic studies that deal with the relationship between paradoxical sleep and anxiety. The great […]

In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

Javier Bustamante Mamani, Jackeline Moraes Malheiros, Ellison Fernando Cardoso, Alberto Tannús, Paulo Henrique Silveira, Lionel Fernel Gamarra

DOI: 10.1590/S1679-45082012000200009

Objective:The aim of the current study was to monitor the migration of superparamagnetic iron oxide nanoparticle (SPION)-labeled C6 cells, which were used to induce glioblastoma tumor growth in an animal model, over time using magnetic resonance imaging (MRI), with the goal of aiding in tumor prognosis and therapy.METHODS:Two groups of male Wistar rats were used for the tumor induction model. In the first group (n=3), the tumors were induced via the injection of SPION-labeled C6 cells. In the second group […]

Multivisceral transplantation in pigs: a model for research and training

André Ibrahim David, Valéria Vieira Chida, Andre Dong Won Lee, Felipe Soares Oliveira Rodrigues Fiuza, Daniela Medeiros Calil, Danielle de Carvalho Mantovani, [...]

DOI: 10.1590/s1679-45082011ao1956

ABSTRACTObjective:To present a model for research and training in multivisceral transplantation in pigs.Methods:Eight Large White pigs (four donors and four recipients) were operated. The multivisceral transplant with stomach, duodenum, pancreas, liver and intestine was performed similarly to transplantation in humans with a few differences, described below. Anastomoses were performed as follows: end-to-end from the supra-hepatic vena cava of the graft to the recipient juxta diaphragmatic vena cava; end-to-end from the infra-hepatic vena cava of the graft to the inferior (suprarenal) […]