2 results

Evaluation of hydroxyurea genotoxicity in patients with sickle cell disease

Emanuel Almeida Moreira de Oliveira ORCID logo , Kenia de Assis Boy ORCID logo , Ana Paula Pinho Santos ORCID logo , Carla da Silva Machado ORCID logo , Cibele Velloso-Rodrigues ORCID logo , Pâmela Souza Almeida Silva Gerheim ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4742

ABSTRACT Objective To evaluate the induction of DNA damage in peripheral blood mononuclear cells of patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea. Methods The study subjects were divided into two groups: one group of 22 patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea, and a Control Group composed of 24 patients with sickle cell disease who were not treated with hydroxyurea. Peripheral blood samples were submitted to peripheral blood mononuclear cell […]

Incidence of variant hemoglobins in newborns attended by a public health laboratory

Flávia Mylla de Sousa Reis, Renata Rodrigues de Oliveira Castelo Branco, Amanda Mota Conceição, Letícia Paula Benvindo Trajano, José Felipe Pinheiro do Nascimento Vieira, Pablo Ricardo Barbosa Ferreira, [...]

DOI: 10.1590/S1679-45082018AO4150

ABSTRACT Objective To evaluate the incidence of variant hemoglobins in different health regions. Methods A descriptive, observational, and cross-sectional study with a quantitative approach based on secondary data in the internal records of the neonatal screening service – Laboratório Central de Saúde Pública do Estado do Piauí (PI, Brazil). The variables related to sex, ethnicity and positive diagnosis for variant hemoglobins were analyzed, with further population distribution of hemoglobinopathies among the macroregions of the state. Results A total of 69,180 […]