All publications of “Kenia de Assis Boy”

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Evaluation of hydroxyurea genotoxicity in patients with sickle cell disease

Emanuel Almeida Moreira de Oliveira ORCID logo , Kenia de Assis Boy ORCID logo , Ana Paula Pinho Santos ORCID logo , Carla da Silva Machado ORCID logo , Cibele Velloso-Rodrigues ORCID logo , Pâmela Souza Almeida Silva Gerheim ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4742

ABSTRACT Objective To evaluate the induction of DNA damage in peripheral blood mononuclear cells of patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea. Methods The study subjects were divided into two groups: one group of 22 patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea, and a Control Group composed of 24 patients with sickle cell disease who were not treated with hydroxyurea. Peripheral blood samples were submitted to peripheral blood mononuclear cell […]