einstein (São Paulo). 01/Mar/2014;12(1):96-9.

Successful management of neonatal alloimmune thrombocytopenia in the second pregnancy: a case report

Fabiana Mendes Conti, Sergio Hibner, Thiago Henrique Costa, Marcia Regina Dezan, Maria Giselda Aravechia, Ricardo Antonio D’Almeida Pereira, Andrea Tiemi Kondo, Élbio Antônio D’Amico, Mariza Mota, José Mauro Kutner

DOI: 10.1590/S1679-45082014RC2729

Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the first child is affected with fetal and/or neonatal thrombocytopenia. There is a significant risk of intracranial hemorrhage and severe neurological impairment, with a tendency for earlier and more severe thrombocytopenia in subsequent pregnancies. This article reports a case of neonatal alloimmune thrombocytopenia in the second pregnancy affected and discusses diagnosis, management and the clinical importance of this disease.

Successful management of neonatal alloimmune thrombocytopenia in the second pregnancy: a case report

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