The journal einstein (São Paulo) – e-ISSN 2317-6385 is dedicated to dissemination of high-quality scientific content that advances our understanding of human disease with the goal of improving prevention, care, diagnostics and treatment of patients globally.
This letter is designed to complement data published by Silva et al., ( ) presenting the results of plasma concentrations of patients who used piperacillin (PIP) in an empirical dose (ED) or dose adjusted (DA) by means of the software Optimum Dosing Strategies (ID-ODS). In addition, it describes some limiting aspects observed by the authors when using the software in the reality of a Brazilian hospital.
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Software for dose adjustment of antimicrobials. Implications for plasma concentrations and pratical limitations
AlvesGCS, SilvaSD, ChequerFMD, CastroWV, BaldoniAO, FarkasA, DarócziG, et al. Software for dose adjustment of antimicrobials. Implications for plasma concentrations and pratical limitations. Einstein (Sao Paulo). 2020;18:eCE5858. https://doi.org/10.31744/einstein_journal/2020CE5858
Alves,Geisa Cristina da Silva; Silva,Samuel Dutra da; Chequer,Farah Maria Drumond; Castro,Whocely Victor de; Baldoni,André Oliveira; Farkas,Andras; Daróczi,Gergely; Roberts,Jason Alexander; Sanches,Cristina. Software for dose adjustment of antimicrobials. Implications for plasma concentrations and pratical limitations. Einstein (Sao Paulo)., v. 18, eCE5858, Oct. 2020. https://doi.org/10.31744/einstein_journal/2020CE5858
Alves,G.C.S., Silva,S.D. , Chequer,F.M.D., Castro,W.V. , Baldoni,A.O., Farkas,A., Daróczi,G., Roberts,J.A., & Sanches,C. (2020). Software for dose adjustment of antimicrobials. Implications for plasma concentrations and pratical limitations. Einstein (Sao Paulo).,18, eCE5858. https://doi.org/10.31744/einstein_journal/2020CE5858
Alves,Geisa Cristina da Silva and Silva,Samuel Dutra da and Chequer,Farah Maria Drumond and Castro,Whocely Victor de and Baldoni,André Oliveira and Farkas,Andras and Daróczi,Gergely and Roberts,Jason Alexander and Sanches,Cristina. Software for dose adjustment of antimicrobials. Implications for plasma concentrations and pratical limitations. Einstein (Sao Paulo). [online]. 2020, vol. 18, [cited 2025-09-07], eCE5858. Available from: <https://journal.einstein.br/article/software-for-dose-adjustment-of-antimicrobials-implications-for-plasma-concentrations-and-pratical-limitations/>. ISSN 1679-4508. https://doi.org/10.31744/einstein_journal/2020CE5858
Figure 5
Risk of bias assessment of non-RCTs using the ROBINS-I tool
Non-RCT, nonrandomized controlled trial; ROBINS-I, Risk of Bias in Non-Randomized Studies-of Interventions
