Inflammation and all-cause mortality in patients undergoing peritoneal dialysis

Higher plasma levels of CCL2 and lower plasma levels of TNF-α are associated with a greater risk of transfer to hemodialysis or mortality.
Lower levels of IL-17 in the dialysate are associated with a greater risk of transfer to hemodialysis or mortality.
These findings suggest that inflammatory biomarkers can be valuable tools for predicting all-cause mortality and transfer to hemodialysis in patients undergoing peritoneal dialysis.

ABSTRACT

Objective:

This study aimed to evaluate inflammatory biomarkers in patients undergoing peritoneal dialysis and investigate their association with all-cause mortality or transfer to hemodialysis.

Methods:

This prospective cohort study included 43 patients undergoing peritoneal dialysis. Plasma levels of cytokines were measured using flow cytometry and capture enzyme-linked immunosorbent assay. Biomarkers were categorized based on their respective median values. Survival analysis was conducted using the Kaplan-Meier estimator, considering two outcomes: all-cause mortality and transfer to hemodialysis.

Results:

After adjusting for confounding factors, plasma levels above the median of the levels of CCL2 and plasma, as well as below the median of TNF-α, and the median of dialysate IL-17 levels, were associated with an increased risk of experiencing the specified outcomes after approximately 16 months of follow-up.

Conclusion:

These findings suggest that inflammatory biomarkers may be a valuable tool for predicting allcause mortality and transfer to hemodialysis in patients undergoing peritoneal dialysis.

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Inflammation and all-cause mortality in patients undergoing peritoneal dialysis

Keywords: Peritoneal dialysis; Cytokines; Peritoneum; Membranes; Mortality; Inflammation

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