einstein (São Paulo). 22/Jul/2024;22:eAO0627.

Inflammation and all-cause mortality in patients undergoing peritoneal dialysis

Wander Valadares de Oliveira , Luciane Teixeira Passos , Letícia Gonçalves Resende , Isabella Viana Gomes , Sylvia Dias , Arlindo Ribeiro de , Maria Aparecida Silva , Sérgio Wyton Lima , Melina , Roberta Carvalho de , Danyelle Romana Alves

DOI: 10.31744/einstein_journal/2024AO0627

Highlights

Higher plasma levels of CCL2 and lower plasma levels of TNF-α are associated with a greater risk of transfer to hemodialysis or mortality.
Lower levels of IL-17 in the dialysate are associated with a greater risk of transfer to hemodialysis or mortality.
These findings suggest that inflammatory biomarkers can be valuable tools for predicting all-cause mortality and transfer to hemodialysis in patients undergoing peritoneal dialysis.

ABSTRACT

Objective:

This study aimed to evaluate inflammatory biomarkers in patients undergoing peritoneal dialysis and investigate their association with all-cause mortality or transfer to hemodialysis.

Methods:

This prospective cohort study included 43 patients undergoing peritoneal dialysis. Plasma levels of cytokines were measured using flow cytometry and capture enzyme-linked immunosorbent assay. Biomarkers were categorized based on their respective median values. Survival analysis was conducted using the Kaplan-Meier estimator, considering two outcomes: all-cause mortality and transfer to hemodialysis.

Results:

After adjusting for confounding factors, plasma levels above the median of the levels of CCL2 and plasma, as well as below the median of TNF-α, and the median of dialysate IL-17 levels, were associated with an increased risk of experiencing the specified outcomes after approximately 16 months of follow-up.

Conclusion:

These findings suggest that inflammatory biomarkers may be a valuable tool for predicting allcause mortality and transfer to hemodialysis in patients undergoing peritoneal dialysis.

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Inflammation and all-cause mortality in patients undergoing peritoneal dialysis
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