Expression profiles of miR-23a andmiR-146a in the peripheral blood of women with premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a clinical syndrome characterized by oligo/amenorrhea observed in women before the age of 40 years, lasting at least 4 months, with elevated follicle-stimulating hormone (FSH) levels.⁽⁾ Its diagnosis is confirmed by two serum measurements conducted at least 1 month apart that show high FSH levels (>25IU/L) and low estradiol levels.⁽⁾ The condition is caused by varying factors, including genetic, immunological, or metabolic factors; iatrogenic intervention; and environmental toxins. The reason is idiopathic in 90% of cases.^(-) Awareness about the signs and symptoms of this condition can be useful for early diagnosis, accurate identification, and early treatment, such as hormone therapy.^(,,) However, besides FSH, no other biomarkers have been identified for screening this condition.

Circulating microRNAs (miRNAs) have been shown to be potential biomarkers for detecting various diseases owing to their unique characteristics in body fluids, including the peripheral blood.⁽⁾ In addition to being minimally invasive, high-precision circulating miRNAs can complement conventional markers. The relationship between miRNAs and POI has drawn increasing interest in biomedical research, with recent studies showing correlations between circulating miRNAs and POI in different populations.^(-)

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Keywords: Primary ovarian insufficiency; Peripheral blood; Biomarkers; Autoimmunity; MicroRNAs; Inflammation

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