einstein (São Paulo). 19/Oct/2023;21:eAO0465.
Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model
DOI: 10.31744/einstein_journal/2023AO0465
Highlights
The predominance of neutrophils was observed in an acute model of gout in mice, where neutrophils were mobilized and gradually replaced by monocytes/macrophages, with attenuation of the influence of leukocyte infiltration in the synovial fluid.
Mobilization promotes analgesia and modulates the inflammatory process due to reduced edema and subtle attenuation of cell migration.
At the inflammatory peak in a gouty arthritis model, manual therapy and passive joint mobilization decrease nociception and edema in functional and inflammatory parameters.
ABSTRACT
Objective:
Gouty arthritis is characterized by painful inflammation due to the deposition of monosodium urate crystals in joint tissues. Despite available treatments, many patients experience ineffective management and adverse effects. This study evaluated a manual therapy protocol involving passive joint mobilization at the peak of inflammation in a gouty arthritis model using functional and inflammatory parameters.
Methods:
Twenty male Wistar rats, 12 weeks old, were divided into two groups (n=10 each): Gouty Arthritis and Control Groups, which were further subdivided into treated and untreated groups (n=5 each). The Gouty Arthritis Group received intraarticular knee injection of 50μL of monosodium urate crystals, while the Control Group received 50μL of phosphate buffered saline. The treatment involved a 9-minutes session of grade III joint mobilization (according to Maitland). Nociception, grip strength, and edema were evaluated before induction (EV0), 7 hours after assessment (EV1), immediately after treatment (EV2), and 1 hour after treatment (EV3). The animals were euthanized, and synovial fluid was collected to analyze leukocyte migration.
Results:
The model mimicked the signs of the Gouty Arthritis Group, with a decrease in the threshold of nociception and strength and an increase in edema and leukocyte count. The mobilization protocol significantly increased the nociceptive threshold and grip strength and reduced edema; however, it did not reverse the increase in leukocyte count.
Conclusion:
Our results suggest that mobilization promotes analgesia and may modulate the inflammatory process owing to reduced edema and subtle attenuation of cell migration, which contributes to strength gain.
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Keywords: Arthritis, gouty; Inflammation; Leukocytes; Synovial fluid; Edema; Models, theoretical; Rats, Wistar
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