Highlights ■ Sex plays a crucial role in behavioral assessments of preclinical study designs. ■ Circadian rhythm influences episodic memory performance in rodent behavior. ■ Spatial memory exhibits fewer variations than locomotion and episodic memory. ■ Sex and the circadian cycle are critical factors in behavioral assessment. ABSTRACT Objective: This study aimed to investigate the effects of sex and time of day on behavioral parameters in healthy rats, focusing on locomotion, cognition, and memory (both spatial and episodic). Methods: Twenty-four […]

Highlights ■ Brazil had a higher upper limb vascular trauma incidence than the US, remaining stable over the years. ■ The region with the highest proportion of cases was the North, followed by the Southeast. ■ The most affected population was young men, with a lethality of 2.37%, comparable to that globally. ■ Most patients did not require intensive care (92.8%), and the average hospital stay was 4.39 days. ABSTRACT Objective: To evaluate the epidemiology of upper limb vascular trauma […]

Highlights ■ All variables that affect the quality of cardiopulmonary resuscitation were analyzed. ■ In addition to performance, we analyzed participants’ confidence. ■ This study considered the cost of training using the traditional methodology versus feedback. ABSTRACT Objective: To analyze cardiopulmonary resuscitation skill acquisition and retention at 3 and 6-month intervals and determine the optimal training frequency and associated costs. Methods: Fifth and sixth-year medical students practiced cardiopulmonary resuscitation using a feedback-equipped simulator. Results: The study included 43 students. Training […]

Highlights ■Most students have a positive attitude towards medical artificial intelligence. ■ Artificial intelligence solutions would be frequently adopted if accurate, fast, and user-friendly. ■ Expectations include work facilitation and increased diagnosis and management speed. ■Most fear losing medical skills to artificial intelligence and desire governmental regulations. ABSTRACT Objective: To assess medical students’ attitudes, knowledge, opinions, and expectations regarding medical artificial intelligence solutions, according to their sex and year of study. Methods: This cross-sectional survey was a single-center study conducted […]

Highlights ■ Higher miR-23a levels in patients with premature ovarian insufficiency vs. normovulatory women. ■ Lower miR-146a levels in patients with premature ovarian insufficiency vs. normovulatory women. ■ Novel biomarkers for early diagnosis and monitoring of premature ovarian insufficiency. ■ Potential biomarkers to therapeutic targets for premature ovarian insufficiency. ABSTRACT Objective: This study aimed to analyze the expression profiles of miR-23a and miR-146a in women with premature ovarian insufficiency and to evaluate their value as biomarkers of the disease for […]

Highlights ■ First study to investigate associations between cognitive performance and brain magnetic resonance imaging parameters in an older Brazilian population. ■ Uses advanced magnetic resonance imaging diffusion tensor imaging and automated analysis to quantify brain changes. ■ Validates findings through comparison with data from a large UK-based cohort. ■ Focuses on region-specific assessments, such as the superior longitudinal fasciculus and other key brain areas related to cognition. ■ Demonstrates significant correlation between 3MS and MMSE cognitive scores and diffusion […]

 Highlights ■ The average total QAS-Tele score was 4.71±0.54 out of 5. ■ Higher satisfaction was reported by older adults in the younger age range. ■ Higher satisfaction was reported by individuals currently working. ■ Higher satisfaction was reported by individuals with a higher number of comorbidities. ABSTRACT Objective: This retrospective observational study analyzed satisfaction with a telehealth service in older individuals living in a metropolitan city in Brazil. Methods: Sociodemographic, clinical, and telehealth service details (number of clinical appointments […]

Highlights ■ Net Promoter Scores of 85 and 91 among patients and physicians, respectively, over three years. ■ A total of 99.3% of patients were satisfied with the teleconsultation. ■ A total of 98.5% of physicians reported overall satisfaction with the program. ■ Surveys reflect excellence in telemedicine expert consultation. ABSTRACT Objective: Telemedicine via teleconsultations enhances access to specialized care. However, the degree of satisfaction among patients and providers with this method remains unclear. This study assessed patient and on-site […]

Highlights ■ Public hospitals in Brazil performed 37,741 hallux valgus surgery procedures between January 2008 and October 2024. ■ The study population consisted of 79.7% females, with the most common age group being 40-69 years (67.7%). The mean length of stay was 1.7 days. ■ The mean cost per patient was US$ 141.53. ■ The overall mortality count was nine, corresponding to a death rate of 0.024%. ABSTRACT Objective: This study aimed to describe patient profiles and analyze costs, hospital […]

Highlights ■ Previous studies have correlated inflammation with complications after percutaneous coronary intervention. ■ In patients with stable coronary disease, percutaneous coronary intervention leads to elevated inflammatory biomarker levels. ■ The inflammatory response is significantly correlated with myocardial injury. ABSTRACT Introduction: In acute coronary syndrome, the release of inflammatory and myocardial injury biomarkers after percutaneous coronary intervention is associated with poor prognosis. However, little is known about the association between these biomarkers in patients with stable disease. Objective: We aimed […]