Highlights ■ SR-B1 knockdown inhibits breast cancer cell proliferation and migration. ■ Silencing SR-B1 promotes apoptosis in breast cancer cells. ■ PI3K/AKT pathway activity decreases after SR-B1 knockdown. ■ Cyclin D1 and P70 are downregulated following SR-B1 silencing. ABSTRACT Background: The role of scavenger receptor class B type 1 (SR-B1) in breast cancer remains largely unknown. Objective: This study aimed to investigate the effects of SR-B1 on breast cancer cell proliferation, migration, and invasion and to elucidate the underlying mechanisms. […]