19/Aug/2025
Overall and disease-free survival in patients with HPV-positive and HPV-negative oropharyngeal cancer
DOI: 10.31744/einstein_journal/2025AO1525
Highlights ■ HPV+ is associated with improved overall survival in oropharyngeal cancer ■ HPV+ tumors tend to recur earlier than HPV- tumors. ■ Metastasis is a key prognostic factor for mortality and recurrence regardless of HPV status. ■ Smoking and alcohol consumption reduce the favorable prognosis of HPV+. ABSTRACT Objective: To analyze the overall and disease-free survival of patients with oropharyngeal squamous cell carcinoma. Methods: Sociodemographic and clinical data, HPV status, and alcohol/tobacco consumption were assessed among patients treated at […]
Keywords: Disease-free survival; Human papillomavirus viruses; Oropharyngeal neoplasms; Prognosis; Recurrence; Squamous cell carcinoma of head and neck; Survival rate
07/Apr/2025
Comparative analysis of miRNA-mRNA interaction prediction tools based on experimental head and neck cancer data
DOI: 10.31744/einstein_journal/2025AO1372
Highlights ■ miRWalk had the highest predicted interactions and validated miRNA networks in HNSCC. ■ Around 3.3% of interactions overlapped across tools, emphasizing the need for multitool approaches. ■ Dysregulated genes and miRNAs were tied to cancerdriving PI3K-Akt and Wnt pathways. ■ The validated approach highlights the importance of integrating computational and molecular data. ABSTRACT Objective: Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis largely due to late diagnosis and a lack of reliable biomarkers. MicroRNAs (miRNAs), […]
Keywords: Algorithms; Biomarkers; Computational biology; Gene expression; MicroRNAs; Squamous cell carcinoma of head and neck; Target prediction tool