17/Oct/2024
Laboratory profiles of patients hospitalized with COVID-19 pneumonia treated with tofacitinib or placebo: a post hoc analysis from the STOP-COVID trial
einstein (São Paulo). 17/Oct/2024;22:eAO0821.
View Article17/Oct/2024
Laboratory profiles of patients hospitalized with COVID-19 pneumonia treated with tofacitinib or placebo: a post hoc analysis from the STOP-COVID trial
DOI: 10.31744/einstein_journal/2024AO0821
Highlights Tofacitinib use did not result in meaningful changes in hematological parameters. Tofacitinib use did not lead to clinically meaningful changes in liver enzymes. ABSTRACT Objective: Tofacitinib, an oral Janus kinase inhibitor, has been tested against a placebo in 289 patients with COVID-19 pneumonia. We analyzed the data from the tofacitinib- and placebotreated patient cohorts to evaluate the laboratory profiles between baseline and day 7. Methods: We performed post hoc analyses on the following laboratory tests over time during the […]
Keywords: Alanine transaminase; Aspartate aminotransferases; Coronavirus infections; COVID-19; Janus kinase inhibitors; Lab results; Platelet count; Pneumonia; Tofacitinib
20/May/2022
Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study
einstein (São Paulo). 20/May/2022;20:eAO6953.
View Article20/May/2022
Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study
DOI: 10.31744/einstein_journal/2022AO6953
ABSTRACT Objective: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. Methods: A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data […]
Keywords: Coronavirus infections; COVID-19; Multidetector computed tomography; Obesity; Pneumonia; Prognosis; Tomography; X-ray computed
20/Oct/2020
COVID-19 myocarditis: a case report
DOI: 10.31744/einstein_journal/2020RC5876
ABSTRACT A male patient with flu-like symptoms and tomography and laboratory diagnosis of severe acute respiratory syndrome. He developed acute cardiac dysfunction during admission and was submitted to a cardiac magnetic resonance imaging examination, which confirmed acute myocarditis, indicating cardiac involvement by coronavirus disease 2019. A review and discussion about coronavirus disease 2019-related cardiac manifestations are reported, focusing on the imaging findings to make diagnosis.
Keywords: Cardiomyopathies; Communicable diseases; Coronavirus; Coronavirus infections; COVID-19; Echocardiography; Myocarditis; Pneumonia; Severe acute respiratory syndrome; Tomography, x-ray computed
30/May/2019
Laryngotracheal separation in pediatric patients: 13-year experience in a reference service
DOI: 10.31744/einstein_journal/2019AO4467
ABSTRACT Objective: To evaluate clinical stability of neurologically impaired children and adolescents with recurrent pneumonia submitted to laryngotracheal separation. Methods: Between October 2002 and June 2015, 92 neurologically impaired children from a reference service, with median age of 68.5 months were submitted to laryngotracheal separation. Data were evaluated and statistical analysis was made by Student’s t test and Pearson’s χ2 test (significance level adopted of 95%). Results: Fifty-three children were male (57.6%). Forty-six children required admission to intensive care, and […]
Keywords: aspiration; Child; Larynx/surgery; Nervous system diseases; Pneumonia; Trachea/surgery
01/Apr/2017
Hospitalization costs of severe bacterial pneumonia in children: comparative analysis considering different costing methods
einstein (São Paulo). 01/Apr/2017;15(2):212-9.
View Article01/Apr/2017
Hospitalization costs of severe bacterial pneumonia in children: comparative analysis considering different costing methods
DOI: 10.1590/S1679-45082017GS3855
ABSTRACT Objective To determine and compare hospitalization costs of bacterial community-acquired pneumonia cases via different costing methods under the Brazilian Public Unified Health System perspective. Methods Cost-of-illness study based on primary data collected from a sample of 59 children aged between 28 days and 35 months and hospitalized due to bacterial pneumonia. Direct medical and non-medical costs were considered and three costing methods employed: micro-costing based on medical record review, micro-costing based on therapeutic guidelines and gross-costing based on the […]
Keywords: Child; Costs and cost analysis; Health expenditures; Hospitalization; Medical records; Pneumonia; Unified Health System