Highlights Intrathecal chemotherapy did not increase overall survival or time to neurologic deterioration. Compared with no treatment, systemic therapy with no intrathecal chemotherapy afforded better overall survival. Intrathecal chemotherapy should not postpone or preclude systemic treatment. ABSTRACT Objective: To evaluate whether intrathecal chemotherapy improves clinical outcomes in patients with meningeal carcinomatosis. Methods: This retrospective cohort study included consecutive patients with breast cancer diagnosed with meningeal carcinomatosis. Clinical and treatment data were collected from the patients’ medical charts. The primary outcome […]