ABSTRACT This case documents the clinical pattern of a fibrinopurulent ulcer with a hyperplastic lesion that developed after the initiation of two classes of targeted therapies acting on different components of the mitogen-activated protein kinase signaling pathway (BRAF inhibitors [BRAFi] and MEK inhibitors [MEKi]). A 66-year-old woman was diagnosed with choroidal melanoma in the right eye in 2012 and successfully treated by choroidal melanoma resection. Tumor recurrence was diagnosed 8 years later. Nivolumab and ipilimumab were prescribed, but this combination […]

Objective To compare the level of vitamin D3 in cutaneous melanoma patients, with or without disease activity, with reference values and with patients from a general hospital. Methods The serum levels of vitamin D3 were measured in cutaneous melanoma patients, aged 20 to 88 years, both genders, from January 2010 to December 2013. The samples from the general group were processed at Hospital Israelita Albert Einstein (control group). Data analysis was performed using the Statistics software. Results A total of […]

ABSTRACT Objective: To assess data on survival, recurrence and histological factors in positive and negative sentinel lymph nodes in thin melanoma cases. Methods: A systematic review was conducted on observational studies in four databases (Cochrane Library, Medline, Embase and Lilacs). Positive and negative micrometastases in sentinel lymph node biopsy were compared regarding the clinical outcomes – death and recurrence – and six histological factors – vertical growth phase, Breslow thickness, Clark level, ulceration, regression and mitosis rate. Results: Positive sentinel […]