Highlights ■ One-third of patients older than 65 years exhibit a hyperinflammatory state typical of inflammatory anemia. ■ The pathophysiology of anemia of inflammation is multifactorial. ■ Higher inflammation is associated with high prevalence of anemia and age-associated disorders. ■ The inflammatory state stimulates hepatocytes to produce hepcidin. ■ Understanding the immunomodulatory parameters in  anemia of inflammation may be effective for differential diagnosis and therapeutic approaches. ABSTRACT Objective: This study aimed to assess the relationship between hepcidin, IFN-γ, iron biomarkers, […]