30/Oct/2023
Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth
einstein (São Paulo). 30/Oct/2023;21:eAO0405.
View Article30/Oct/2023
Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth
DOI: 10.31744/einstein_journal/2023AO0405
Highlights Inhibition of endocannabinoid receptors and TNF-α led to an increase in HLA-DR, PD-L1, and PD-L2 levels in stem cells from human exfoliated deciduous teeth. This study shows the interaction between mesenchymal stromal cells and the immune and endocannabinoid systems. ABSTRACT Objective To verify the involvement of the endocannabinoid system in the immunomodulatory profile of stem cells from human exfoliated deciduous teeth, in the presence or absence of TNF-α, and agonist and antagonists of CB1 and CB2. Methods Stem cells […]
Keywords: Endocannabinoids; Immunomodulation; Mesenchymal stem cells; Receptor, cannabinoid, CB1; Receptor, cannabinoid, CB2; Tooth, deciduous; Tumor necrosis factor-alpha
09/Nov/2022
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease
DOI: 10.31744/einstein_journal/2022RW0170
ABSTRACT Alzheimer’s disease is a neurodegenerative condition that causes changes in memory and cognition, in addition to behavioral disorders, and most commonly affects the elderly. Several studies in the literature have presented therapeutic measures in an attempt to interfere with the pathogenic mechanisms of the disease and to mitigate its clinical manifestations. Some factors, such as excitotoxicity, cholinergic dysfunctions, oxidative stress, tau protein hyperphosphorylation, changes in amyloid-beta peptide metabolism, herpes viruses, apolipoprotein E, glycogen synthase kinase 3, insulin resistance, and […]
Keywords: Alzheimer disease; Amyloid beta-peptides; Apolipoprotein E4; Cyclic AMP response element-binding protein; Diabetes mellitus type 3; Endocannabinoids; Glycogen synthase kinase 3; Insulin resistance; Oxidative stress; Tau proteins