2 results

Nosocomial infections by Klebsiella pneumoniae carbapenemase producing enterobacteria in a teaching hospital

Gabriela Seibert, Rosmari Hörner, Bettina Holzschuh Meneghetti, Roselene Alves Righi, Nara Lucia Frasson Dal Forno, Adenilde Salla

DOI: 10.1590/s1679-45082014ao3131

Objective To analyze the profile of patients with microorganisms resistant to carbapenems, and the prevalence of the enzyme Klebsiella pneumoniae carbapenemase in interobacteriaceae.Methods Retrospective descriptive study. From the isolation in bacteriological tests ordered by clinicians, we described the clinical and epidemiological characteristics of patients with enterobacteria resistants to carbapenems at a university hospital, between March and October 2013.Results We included 47 isolated patients in this study, all exhibiting resistance to carbapenems, including 9 patients who were confirmed as infected/colonized with […]

Chronic myeloid leukemia: past, present, future

Patricia Weinschenker Bollmann, Auro del Giglio

DOI: 10.1590/S1679-45082011RB2022

ABSTRACT The discovery of the Philadelphia chromosome in 1960, and of the BCR-ABL oncogene in 1984, enabled the development in subsequent years of a targeted therapy that revolutionized the treatment of chronic myeloid leukemia, thus changing its natural history. The use of imatinib resulted in a significant improvement of the prognosis and outcome of patients with chronic myeloid leukemia. However, the occurrence of mechanisms of resistance or intolerance precludes the eradication of the disease in some of the patients. Second-generation […]