1 results
08/Aug/2025
08/Aug/2025
DOI: 10.31744/einstein_journal/2025AO1601
Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]
Keywords: Biomarkers; Disease progression; Disease-free survival; Health strategies; Lipid metabolism; Lymph nodes; Prognosis; Prostatic neoplasms