13/Aug/2025
A prospective and longitudinal cohort study assessing postacute sequelae of SARS-CoV-2 infection in patients with cancer
einstein (São Paulo). 13/Aug/2025;23:eAO1139.
View Article13/Aug/2025
A prospective and longitudinal cohort study assessing postacute sequelae of SARS-CoV-2 infection in patients with cancer
DOI: 10.31744/einstein_journal/2025AO1139
Highlights High fatigue and nutritional risk at discharge improved over one year in cancer survivors. Psychological symptoms, such as anxiety, depression, and posttraumatic stress disorder, remained prevalent for one year. 66% of patients had lasting symptoms or impairments after 12 months of follow-up. Nutritional risk was resolved in the following year. ABSTRACT Objective: Post-COVID symptoms are frequent and can be debilitating, particularly in individuals with cancer. However, their impact on this population remains unclear. This study aimed to prospectively assess […]
Keywords: Activities of Daily Living; Anxiet; Coronavirus infections; COVID-19; Depression; Fatigue; Hospitalization; Intensive care units; Neoplasms; Patient discharge; Post-acute COVID-19 syndrome; SARS-CoV-2; Stress disorders, post-traumatic; Symptom assessment
22/Apr/2025
Psychological impact of gestational trophoblastic disease: a cross-sectional study
einstein (São Paulo). 22/Apr/2025;23:eAO1014.
View Article22/Apr/2025
Psychological impact of gestational trophoblastic disease: a cross-sectional study
DOI: 10.31744/einstein_journal/2025AO1014
Highlights ■ Gestational trophoblastic disease should be followed up at a referral center. ■ Adequate follow-up improves quality of life for affected women. ■ Multidisciplinary monitoring reduces anxiety and depression in women. ABSTRACT Objective: To evaluate the psychological repercussions of gestational trophoblastic disease. Methods: A cross-sectional study including 100 women (50 with gestational trophoblastic disease and 50 without) was conducted between September 2020 and October 2021. Socio-demographic characteristics, quality of life, depression, and anxiety were evaluated and follow-up was performed […]
Keywords: Anxiety; Depression; Gestational trophoblastic disease; Mental Health; Quality of life; Surveys and questionnaires
14/Mar/2025
Are changes in physical activity associated with depression? A follow-up study of 1,950 individuals
DOI: 10.31744/einstein_journal/2025AO1128
Highlights ■ Persistently active individuals have strong independent protective factors against depression. ■ BMI (kg/m2) is an independent risk factor for depression. ■ Individuals with depression at follow-up were older than those without depression. ■ Perceived stress is a strong independent risk factor for depression. ABSTRACT Objective: To evaluate the association between changes in physical activity and depression in 1,950 Brazilians. Methods: This follow-up study included 1,950 Brazilians, aged ≥18 years, of both sexes, who participated in a health screening […]
Keywords: Depression; Exercise; Exercise therapy; Lifestyle; Sedentary behavior; Surveys and questionnaires
25/Nov/2024
The association between erectile dysfunction and depression: a cross-sectional study of 21,139 Brazilian men
DOI: 10.31744/einstein_journal/2024AO1063
Highlights Levels of lower urinary tract symptoms increased the risk of depression. Erectile dysfunction, alcohol consumption, and body mass index were associated with an increased likelihood of depression. ABSTRACT Objective: This study aimed to investigate the relationship between depression and erectile dysfunction while controlling for sociodemographic, physical health, psychological, and lifestyle factors. Additionally, it aimed to compare erectile dysfunction with other clinical, laboratory, and behavioral variables among individuals with depression in the same population. Methods: We included 21,139 men (≥40 […]
Keywords: Depression; Erectile dysfunction; Exercise; Life style; Obesity
21/Nov/2024
Continuous evaluation of exosomatic electrodermal activity in patients with primary palmoplantar hyperhidrosis
einstein (São Paulo). 21/Nov/2024;22:eAO1152.
View Article21/Nov/2024
Continuous evaluation of exosomatic electrodermal activity in patients with primary palmoplantar hyperhidrosis
DOI: 10.31744/einstein_journal/2024AO1152
Highlights ■ Continuous exosomatic electrodermal activity was associated with higher skin conductance levels in patients with hyperhidrosis. ■ Palmoplantar sweating was significantly higher in the hyperhidrosis group than in the control group (p<0.01). ■ Electrodermal activity is an effective and simple method for objectively quantifying sweating in patients with hyperhidrosis. ABSTRACT Objective: To objectively evaluate sweat intensity in patients with primary hyperhidrosis by measuring electrodermal activity using a continuous exosomatic technique without external stimuli. Methods: This prospective and transversal study […]
Keywords: Anxiety; Depression; Galvanic skin response; Hyperhidrosis; Palmoplantar sweating; Perception; Surveys and questionnaires; Sweat
30/Nov/2023
Relationship between chronic pain, depressive symptoms, and functional disability in community-dwelling older adults: mediating role of frailty
einstein (São Paulo). 30/Nov/2023;21:eAO0284.
View Article30/Nov/2023
Relationship between chronic pain, depressive symptoms, and functional disability in community-dwelling older adults: mediating role of frailty
DOI: 10.31744/einstein_journal/2023AO0284
Highlights Chronic pain is directly associated with depressive symptoms and frailty. Chronic pain is not directly associated with functional disability. Depression and frailty are both directly associated with functional disabilities. Frailty mediates the association between chronic pain and functional disability. ABSTRACT Objective: To evaluate the direct and indirect effects of chronic pain, depressive symptoms, frailty components, and functional disability through a pathway analysis approach in a sample of community-dwelling older adults. Methods: Data of 419 participants were cross-sectionally evaluated for […]
Keywords: Chronic disease; Depression; Disability evaluation; Frail elderly; Frailty; Pain
23/Nov/2023
Perinatal N(G)-Nitro-L-arginine methyl ester administration decreases anxiety- and depression-like behaviors in adult mice
einstein (São Paulo). 23/Nov/2023;21:eAO0302.
View Article23/Nov/2023
Perinatal N(G)-Nitro-L-arginine methyl ester administration decreases anxiety- and depression-like behaviors in adult mice
DOI: 10.31744/einstein_journal/2023AO0302
Highlights Perinatal L-NAME treatment decreased anxiety- and depression-like behaviors in adult mice. Perinatal L-NAME treatment did not promote changes in locomotor activity in adult mice. Perinatal L-NAME treatment did not alter pain perception ABSTRACT Objective: We hypothesized that perinatal manipulations of the nitrergic system would affect adult animal behaviors. Methods: We tested this hypothesis by perinatally administering N(G)-Nitro-L-arginine methyl ester (L-NAME), a non-specific antagonist of nitric oxide synthase for 15 days and assessed anxiety- and depression-like behaviors in adult mice. […]
Keywords: Anxiety; Depression; Mice; NG-nitroarginine methyl ester; Nitric oxide; Pain perception
31/Jul/2023
The effects of gratitude interventions: a systematic review and meta-analysis
DOI: 10.31744/einstein_journal/2023RW0371
ABSTRACT Introduction Gratitude has several implications. Over time, a logical relationship has been established between gratitude and well-being. In addition, researchers aimed to establish associations between gratitude and other factors of positive feelings using scientific methods. We conducted a systematic review and meta-analysis of interventions to develop gratitude and its benefits to human beings. Objective This study aimed to evaluate and quantify the available scientific evidence on interventions to acquire knowledge on gratitude as a quantifiable causal factor of benefit […]
Keywords: Anxiety; Delivery of health care; Depression; Emotions; Gratitude; Health facilities; Mental Health; Narration; Personnel satisfaction
13/Apr/2022
Depression in healthcare workers from the COVID-19 Care and Isolation Center – Villa Panamericana: a single-center prospective study in Peru
einstein (São Paulo). 13/Apr/2022;20:eAO6707.
View Article13/Apr/2022
Depression in healthcare workers from the COVID-19 Care and Isolation Center – Villa Panamericana: a single-center prospective study in Peru
DOI: 10.31744/einstein_journal/2022AO6707
ABSTRACT Objective Depression is a mental problem that affects the well-being of healthcare workers, impacting the quality of care and even leading to commit suicide. We aim to the levels of depression in frontline healthcare workers during the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Peru. Methods A prospective cohort study was designed in the coronavirus disease 2019 (COVID-19) Care and Isolation Center – Villa Panamericana in eastern Lima. Care and Isolation Center-Villa Panamericana houses about 150 […]
Keywords: Betacoronavirus; Coronavirus infections; COVID-19; Depression; Health personnel; Mental Health; Peru; SARS-CoV-2
22/Mar/2022
Clinical outcome analysis in surgical patients enrolled in a Second Opinion Program in spine surgery
DOI: 10.31744/einstein_journal/2022AO5791
ABSTRACT Objective To analyze pain, functional capacity, quality of life, anxiety and depression outcomes in patients undergoing lumbar spine surgery following use of the Second Opinion Program, and to present disagreements regarding diagnoses and therapeutic indications between the first and second opinions. Methods A prospective, observational cohort study with 100 patients enrolled in the Second Opinion Program who underwent lumbar spine surgery. Questionnaires addressing pain intensity, level of disability, quality of life, anxiety and depression were applied prior to and […]
Keywords: Anxiety; Arthrodesis; Depression; Low back pain; Pain management; Quality of life; Referral and consultation; Spinal diseases/surgery; Treatment outcome