28/Apr/2025
Mild and moderate manifestations of SARS-CoV-2 infection, including hospitalization, in children and adolescents with cystic fibrosis
einstein (São Paulo). 28/Apr/2025;23:eAO1312.
View Article28/Apr/2025
Mild and moderate manifestations of SARS-CoV-2 infection, including hospitalization, in children and adolescents with cystic fibrosis
DOI: 10.31744/einstein_journal/2025AO1312
Highlights ■ SARS-CoV-2 infection leads to mild-to-moderate disease in children with cystic fibrosis. ■ No worsening of cystic fibrosis was observed months after infection. ABSTRACT Objective: This study aimed to evaluate the clinical manifestations of SARS-CoV-2 in children and adolescents with cystic fibrosis. Methods: This was a case-control analysis of clinical variables and pulmonary function test results in 43 children with cystic fibrosis, 17 (39.5%) of whom tested positive for SARS-CoV-2. Results: The infected children exhibited a higher frequency of […]
Keywords: Adolescent; Adolescent, hospitalized; Child; Child, hospitalized; Coronavirus infections; Cystic fibrosis; Hospitalization; Respiratory function tests; SARS-CoV-2; Virus diseases
22/Mar/2022
Brazilian Guidelines for Nutrition in Cystic Fibrosis
DOI: 10.31744/einstein_journal/2022RW5686
ABSTRACT Objective To develop a scientific consensus on nutrition in cystic fibrosis. Methods Sixteen coordinators elaborated relevant questions on nutritional therapy in cystic fibrosis, which were divided into six sections: nutritional assessment, nutritional recommendations, nutritional intervention, dietary counseling, special situations and enzyme replacement, and gastrointestinal manifestations. Two to three specialists in the field were responsible for each section and obtaining answers formulated based on standardized bibliographic searches. The available literature was searched in the PubMed®/MEDLINE database, after training and standardization […]
Keywords: Cystic fibrosis; Nutrition therapy; Nutritional assessment; Recommended dietary allowances
30/Oct/2018
Medications used in pediatric cystic fibrosis population
DOI: 10.31744/einstein_journal/2018AO4212
ABSTRACT Objective To describe the drug utilization profile used by pediatric cystic fibrosis patients. Methods A transversal study comprising the analysis of records and interviews with caregivers of pediatric patient in a reference center of Southern Brazil. We collected information about patients’ clinical condition, medication used and household therapy. Results Out of 78 patients participating in the study, prevailing characteristics were: female, self-declared white color, mutation F508del and countryside resident. Forty-three patients had health monitoring exclusively in the hospital’s outpatient […]
Keywords: Caregivers; Child; Cystic fibrosis; Drug utilization; Pharmaceutical preparations; Pharmaceutical services
19/Apr/2018
Association between hypovitaminosis D and frequency of pulmonary exacerbations in children and adolescents with cystic fibrosis
DOI: 10.1590/S1679-45082018AO4143
Abstract Objective We evaluated the association between vitamin D levels and nutritional status, pulmonary function and pulmonary exacerbations in children and adolescents with cystic fibrosis. Methods 25-hydroxyvitamin D (25(OH)D) levels of 37 children and adolescents were retrospectively evaluated. Pulmonary function, body mass index, height for age, and pulmonary exacerbations episodes were associated with vitamin D levels divided into two groups: sufficient (≥30ng/mL) and hypovitaminosis (
Keywords: Adolescent; Avitaminosis; Child; Cystic fibrosis; Symptom flare up; Vitamin D
01/Jan/2015
Preimplantation genetic diagnosis for cystic fibrosis: a case report
DOI: 10.1590/S1679-45082015RC2738
Cystic fibrosis is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene. This disorder produces a variable phenotype including lung disease, pancreatic insufficiency, and meconium ileus plus bilateral agenesis of the vas deferens causing obstructive azoospermia and male infertility. Preimplantation genetic diagnosis is an alternative that allows identification of embryos affected by this or other genetic diseases. We report a case of couple with cystic fibrosis; the woman had the I148 T mutation and […]
Keywords: Case reports; Cystic fibrosis; Fertilization in vitro; Preimplantation genetic diagnosis