The journal einstein (São Paulo) – e-ISSN 2317-6385 is dedicated to dissemination of high-quality scientific content that advances our understanding of human disease with the goal of improving prevention, care, diagnostics and treatment of patients globally.
Hypervitaminosis D is a rarely reported condition. In general it is only perceived when hypercalcemia is not resolved. The use of vitamin D has increased in recent years because of its benefits, but as a result, intoxication cases have occurred more frequently. This report describes a patient who presented worsening of renal function and hypercalcemia. After investigation, vitamin D intoxication was confirmed and it was due to an error in compounding.
MarinsTA, GalvãoTFG, KorkesF, MalerbiDAC, GancAJ, KornD, WagnerJ, et al. Vitamin D intoxication: case report. Einstein (Sao Paulo). 2014;12(2):242-4. https://doi.org/10.1590/S1679-45082014RC2860
Marins,Tatiana Aporta; Galvão,Tatiana de Fátima Gonçalves; Korkes,Fernando; Malerbi,Domingos Augusto Cherino; Ganc,Arnaldo José; Korn,Davi; Wagner,Jairo; Guerra,João Carlos de Campos; Borges Filho,Wladimir Mendes; Ferracini,Fábio Teixeira; Korkes,Hélio. Vitamin D intoxication: case report. Einstein (Sao Paulo)., v. 12, n. 2, p. 242-244, Apr. 2014. https://doi.org/10.1590/S1679-45082014RC2860
Marins,T.A., Galvão,T.F.G., Korkes,F., Malerbi,D.A.C., Ganc,A.J., Korn,D., Wagner,J., Guerra,J.C.C., Borges Filho,W.M., Ferracini,F.T., & Korkes,H. (2014). Vitamin D intoxication: case report. Einstein (Sao Paulo).,12(2), 242-244. https://doi.org/10.1590/S1679-45082014RC2860
Marins,Tatiana Aporta and Galvão,Tatiana de Fátima Gonçalves and Korkes,Fernando and Malerbi,Domingos Augusto Cherino and Ganc,Arnaldo José and Korn,Davi and Wagner,Jairo and Guerra,João Carlos de Campos and Borges Filho,Wladimir Mendes and Ferracini,Fábio Teixeira and Korkes,Hélio. Vitamin D intoxication: case report. Einstein (Sao Paulo). [online]. 2014, vol. 12, n. 2, [cited 2026-06-27], pp.242-244. Available from: <https://journal.einstein.br/article/vitamin-d-intoxication-case-report/>. ISSN 1679-4508. https://doi.org/10.1590/S1679-45082014RC2860
Figure 5
DNA triple helix (triplex) structures. A) Three-dimensional view of an intramolecular DNA triplex solved by solution-state nuclear magnetic resonance (PDB ID: 1BCB). The structure was deposited by Asensio et al. (1998) and classified as DNA without mutations.(20) This triple helical arrangement illustrates the association of a third strand with the canonical duplex, stabilized by Hoogsteen interactions. B) Simplified schematic (adapted from Brazda et al., 2020; and Holder et al., 2015) illustrating the principle of triplex formation.(22,23) The canonical duplex is stabilized by Watson–Crick base pairs, while the third strand binds in the major groove via Hoogsteen hydrogen bonds. The chemical structure shown in green corresponds to adenine from the third strand, forming a representative T·A·T triad with a Watson–Crick A·T base pair. Such alternative base-pairing interactions enable an additional strand to associate with duplex DNA through Hoogsteen hydrogen bonding, generating a triple-helical structure capable of modulating essential processes such as replication and transcription
