einstein (São Paulo). 02/May/2022;20:eAO6828.

Relation between red blood cell distribution width and acute kidney injury in patients with sepsis

Marina Larissa Vettorello , Manoela Fidelis Batista , Daniel Zu Yow , Leonardo Bonilla da , Leonardo José Rolim , Andreia , Araci Massami , Andrea Tiemi , Guilherme Benfatti , Marcelino de Souza Durão , Adelson Marçal , Daniela Mendes , Danilo Candido de , Miguel Angelo

DOI: 10.31744/einstein_journal/2022AO6828

ABSTRACT

Objective

The objective of the present study is to evaluate the association of red blood cell distribution width with acute kidney injury in sepsis.

Methods

This is a retrospective study of 849 critically ill patients with sepsis in intensive care unit. Demographic data, renal function, inflammation, complete blood count, and acid-base parameters were compared between acute kidney injury and non-acute kidney injury groups. Therefore, a multivariate analysis was performed to observe independent predictive factors.

Results

Comparatively, higher levels of C-reactive protein, lactate, red blood cell distribution width, and Simplified Acute Physiology Score 3 were found in the acute kidney injury group. The study showed a higher frequency of women, hemoglobin (Hgb) concentration, platelets, bicarbonate and PaO2/FiO2 ratio in the non-acute kidney injury group. In addition, there was an independent association of comorbidity-chronic kidney disease [OR 3.549, 95%CI: 1.627-7.743; p<0.001], urea [OR 1.047, 95%CI: 1.036-1.058; p<0.001] and RDW [OR 1.158, 95%CI: 1.045-1.283; p=0.005] with acute kidney injury in sepsis patients.

Conclusion

As an elective risk factor, red blood cell distribution width was independently associated with sepsis-related acute kidney injury. Thus, red blood cell distribution width acts like a predictive factor for sepsis-induced acute kidney injury in intensive care unit admission.

Relation between red blood cell distribution width and acute kidney injury in patients with sepsis
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