einstein (São Paulo). 28/Apr/2025;23:eAO1312.
Mild and moderate manifestations of SARS-CoV-2 infection, including hospitalization, in children and adolescents with cystic fibrosis
DOI: 10.31744/einstein_journal/2025AO1312
Highlights
■ SARS-CoV-2 infection leads to mild-to-moderate disease in children with cystic fibrosis.
■ No worsening of cystic fibrosis was observed months after infection.
ABSTRACT
Objective:
This study aimed to evaluate the clinical manifestations of SARS-CoV-2 in children and adolescents with cystic fibrosis.
Methods:
This was a case-control analysis of clinical variables and pulmonary function test results in 43 children with cystic fibrosis, 17 (39.5%) of whom tested positive for SARS-CoV-2.
Results:
The infected children exhibited a higher frequency of dyspnea and cough and a greater need for hospitalization. One infected child died. Pulmonary exacerbations were more frequent among the infected children. Additional data indicated a subsequent reduction in pulmonary function in the infected children, although this was not significantly different from that in the uninfected children.
Conclusion:
Children with cystic fibrosis who contracted SARSCoV- 2 experienced mild to moderate symptoms and required hospitalization but generally had high recovery rates.
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