Cortical ribbon sign on neuroimaging in a patient with hepatic encephalopathy secondary to herbal medicine usage

The use of herbal medicines is growing exponentially despite the lack of scientific evidence regarding their effectivity and toxicity. ^{( , )} Moreover, the use of herbal medicines have been reported to be common in patients with chronic liver disease (30–62%); these medicines can lead to hepatotoxicity and serious hepatic side effects. ^{( )} Hepatic encephalopathy is a complication of acute liver failure and chronic liver disease that causes cognitive dysfunction, motor deficits, and seizures. ^{( , )} Gastrointestinal hemorrhage, infection, dehydration, constipation, and use of medications are the most common precipitating factors. ^{( )}

This study reports the case of a previously healthy 37-year-old woman who developed acute liver failure and hepatic encephalopathy (international normalized ratio 3.5, total bilirubin 30.2mg/dL, direct bilirubin 15.5mg/dL, aspartate aminotransferase 423U/L, and alanine aminotransferase 459U/L) after consuming an herbal medicine ( Citrus sinensis ) for lose weight. The patient went to the hospital due to jaundice and malaise, being hospitalized for evaluation. She underwent brain magnetic resonance imaging (MRI) due to lethargy, revealing cortical ribbon sign in diffusion-weighted and fluid-attenuated inversion recovery (FLAIR) sequences and hypersignal in the caudate nuclei, putamen, and insula bilaterally ( ). The cortical ribbon sign is a typical finding in patients with Creutzfeldt–Jakob disease; however, it has also been reported in patients with infection, hypoxia, electrolyte derangements, and hepatic encephalopathy (as in the present case). ^{( , )} Moreover, magnetic resonance spectroscopy revealed an increase in glutamate/glutamine, typically observed in hepatic encephalopathy ( ). Owing to the severity of the condition, the patient underwent liver transplantation and is improving progressively.

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