The journal einstein (São Paulo) – e-ISSN 2317-6385 is dedicated to dissemination of high-quality scientific content that advances our understanding of human disease with the goal of improving prevention, care, diagnostics and treatment of patients globally.
In this issue of einstein journal (São Paulo), Corrêa et al., reported intensive support recommendations for critically-ill patients with suspected or confirmed infection by the new coronavirus (COVID-19).() Based on preliminary demonstration of efficacy of chloroquine, the authors suggested the use of hydroxychloroquine in monotherapy or combined with a macrolide (azithromycin or clarithromycin), to treat severe patients with COVID-19, admitted to the intensive care unit (ICU), to inhibit in vitro replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).()
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Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection
CorrêaTD, MatosGFJ, BravimBA, CordioliRL, GarridoAPG, AssuncaoMSC, BarbasCSV, et al. Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection. Einstein (Sao Paulo). 2020;18:eCE5931. https://doi.org/10.31744/einstein_journal/2020CE5931
Corrêa,Thiago Domingos; Matos,Gustavo Faissol Janot de; Bravim,Bruno de Arruda; Cordioli,Ricardo Luiz; Garrido,Alejandra del Pilar Gallardo; Assuncao,Murillo Santucci Cesar de; Barbas,Carmen Silvia Valente; Timenetsky,Karina Tavares; Rodrigues,Roseny dos Reis; Guimarães,Hélio Penna; Rabello Filho,Roberto; Lomar,Frederico Polito; Scarin,Farah Christina de La Cruz; Batista,Carla Luciana; Pereira,Adriano José; Guerra,João Carlos de Campos; Carneiro,Bárbara Vieira; Nawa,Ricardo Kenji; Brandão,Rodrigo Martins; Pesaro,Antônio Eduardo Pereira; Silva Júnior,Moacyr; Carvalho,Fabricio Rodrigues Torres de; Silva,Cilene Saghabi de Medeiros; Almeida,Ana Claudia Ferraz de; Franken,Marcelo; Pesavento,Marcele Liliane; Eid,Raquel Afonso Caserta; Ferraz,Leonardo José Rolim. Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection. Einstein (Sao Paulo)., v. 18, eCE5931, Jul. 2020. https://doi.org/10.31744/einstein_journal/2020CE5931
Corrêa,T.D., Matos,G.F.J. , Bravim,B.A., Cordioli,R.L., Garrido,A.P.G., Assuncao,M.S.C. , Barbas,C.S.V., Timenetsky,K.T., Rodrigues,R.R., Guimarães,H.P., Rabello Filho,R., Lomar,F.P., Scarin,F.C.L.C., Batista,C.L., Pereira,A.J., Guerra,J.C.C., Carneiro,B.V., Nawa,R.K., Brandão,R.M., Pesaro,A.E.P., Silva Júnior,M., Carvalho,F.R.T. , Silva,C.S.M., Almeida,A.C.F. , Franken,M., Pesavento,M.L., Eid,R.A.C., & Ferraz,L.J.R. (2020). Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection. Einstein (Sao Paulo).,18, eCE5931. https://doi.org/10.31744/einstein_journal/2020CE5931
Corrêa,Thiago Domingos and Matos,Gustavo Faissol Janot de and Bravim,Bruno de Arruda and Cordioli,Ricardo Luiz and Garrido,Alejandra del Pilar Gallardo and Assuncao,Murillo Santucci Cesar de and Barbas,Carmen Silvia Valente and Timenetsky,Karina Tavares and Rodrigues,Roseny dos Reis and Guimarães,Hélio Penna and Rabello Filho,Roberto and Lomar,Frederico Polito and Scarin,Farah Christina de La Cruz and Batista,Carla Luciana and Pereira,Adriano José and Guerra,João Carlos de Campos and Carneiro,Bárbara Vieira and Nawa,Ricardo Kenji and Brandão,Rodrigo Martins and Pesaro,Antônio Eduardo Pereira and Silva Júnior,Moacyr and Carvalho,Fabricio Rodrigues Torres de and Silva,Cilene Saghabi de Medeiros and Almeida,Ana Claudia Ferraz de and Franken,Marcelo and Pesavento,Marcele Liliane and Eid,Raquel Afonso Caserta and Ferraz,Leonardo José Rolim. Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection. Einstein (Sao Paulo). [online]. 2020, vol. 18, [cited 2025-09-06], eCE5931. Available from: <https://journal.einstein.br/article/comment-to-intensive-support-recommendations-for-critically-ill-patients-with-suspected-or-confirmed-covid-19-infection/>. ISSN 1679-4508. https://doi.org/10.31744/einstein_journal/2020CE5931
Figure 5
Risk of bias assessment of non-RCTs using the ROBINS-I tool
Non-RCT, nonrandomized controlled trial; ROBINS-I, Risk of Bias in Non-Randomized Studies-of Interventions
