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Fluorescein is associated with minor adverse effects during retinal angiography, and most of these effects are not severe and not related to immunological mechanism. However, on rare occasions, anaphylatoid reaction can occur, and fatalities involving fluorescein have been described. Life threatening complications after intravenous injection of sodium fluorescein require immediate intervention. Trainings for professionals are needed to standardize treatment for this event.
Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic
BalbinoM, SilvaG, CorreiaGCTP. Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo) 2012;10(3):374-6. https://doi.org/10.1590/S1679-45082012000300021
Balbino,Marcos; Silva,Gisele; Correia,Gabriela Cardoso Tostes Pimentel. Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo), v. 10, n. 3, p. 374-376, Oct. 2012. https://doi.org/10.1590/S1679-45082012000300021
Balbino,M., Silva,G., & Correia,G.C.T.P. (2012). Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo),10(3), 374-376. https://doi.org/10.1590/S1679-45082012000300021
Balbino,Marcos and Silva,Gisele and Correia,Gabriela Cardoso Tostes Pimentel. Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo) [online]. 2012, vol. 10, n. 3, [cited 2026-08-15], pp.374-376. Available from: <https://journal.einstein.br/article/anaphylaxis-with-convulsions-following-intravenous-fluorescein-angiography-at-an-outpatient-clinic/>. ISSN 1679-4508. https://doi.org/10.1590/S1679-45082012000300021
Figure 2
Clinical case illustrating the prevention of medication-related osteonecrosis of the jaw in a patient reporting pain in the left mandibular second molar using zoledronic acid every 6 months for 2 years for osteoporosis. (A) Initial clinical view of the tooth scheduled for extraction. B) Intraoperative view after tooth extraction. (C) Application of methylene blue as a pre-irradiation step for antimicrobial photodynamic therapy. Approximately 1mL of the solution was applied to the extraction socket (100µg/mL) for 1 min. (D) Application of 660nm red light to the socket (100mW; 6J/point). (E) Clinical outcome 2 weeks after tooth extraction. (F) Clinical outcome 8 weeks after surgery, showing complete healing with complete soft tissue covering