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Fluorescein is associated with minor adverse effects during retinal angiography, and most of these effects are not severe and not related to immunological mechanism. However, on rare occasions, anaphylatoid reaction can occur, and fatalities involving fluorescein have been described. Life threatening complications after intravenous injection of sodium fluorescein require immediate intervention. Trainings for professionals are needed to standardize treatment for this event.
Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic
BalbinoM, SilvaG, CorreiaGCTP. Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo) 2012;10(3):374-6. https://doi.org/10.1590/S1679-45082012000300021
Balbino,Marcos; Silva,Gisele; Correia,Gabriela Cardoso Tostes Pimentel. Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo), v. 10, n. 3, p. 374-376, Oct. 2012. https://doi.org/10.1590/S1679-45082012000300021
Balbino,M., Silva,G., & Correia,G.C.T.P. (2012). Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo),10(3), 374-376. https://doi.org/10.1590/S1679-45082012000300021
Balbino,Marcos and Silva,Gisele and Correia,Gabriela Cardoso Tostes Pimentel. Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic. Einstein (São Paulo) [online]. 2012, vol. 10, n. 3, [cited 2025-09-05], pp.374-376. Available from: <https://journal.einstein.br/article/anaphylaxis-with-convulsions-following-intravenous-fluorescein-angiography-at-an-outpatient-clinic/>. ISSN 1679-4508. https://doi.org/10.1590/S1679-45082012000300021
Figure 5
Risk of bias assessment of non-RCTs using the ROBINS-I tool
Non-RCT, nonrandomized controlled trial; ROBINS-I, Risk of Bias in Non-Randomized Studies-of Interventions