Highlights ■ ACE2 rs2285666 GG genotype increased the risk ofintensive care unit risk in women. ■ TNF rs1800629 A allele was associated with severe COVID-19 and invasive mechanical ventilation. ■ IL1A rs1800587 influenced disease severity and respiratory symptoms. ■ TNF polymorphism was associated with post-COVID, cough and fatigue. ABSTRACT Objective: We evaluated the influence of single-nucleotide polymorphisms in cytokine, renin-angiotensin-aldosterone system, and uromodulin genes on COVID-19 severity and the persistence of symptoms in the post-COVID phase. Methods: Two cross-sectional cohort […]