5 results
22/Sep/2025
22/Sep/2025
DOI: 10.31744/einstein_journal/2024AO1467
INTRODUCTION Despite medical advances and numerous efforts to mitigate cognitive decline, aging remains a universal process affecting all individuals.()Cognitive decline complexity in the older population results from the interplay of various aging-related factors, including cellular senescence, epigenetic modifications, and metabolic dysfunction. Brain aging phenotypes, such as vascular dysfunction, inflammation, and lipid dysregulation, further interact with central nervous system processes, leading to morphological, cognitive, and neuropathological changes, ultimately contributing to neurodegenerative diseases.() Dementia, characterized by severe cognitive decline that interferes with […]
Keywords: Aged; Cognition; Cognitive dysfunction; Dementia; Diffusion tensor imaging; Magnetic resonance imaging; Neuroimaging; Neuropsychological tests
18/Oct/2019
DOI: 10.31744/einstein_journal/2020AO4752
ABSTRACT Objective To evaluate the epidemiological profile of patients seen at a dementia outpatient clinic. Methods A retrospective study conducted by medical record review searching data on sex, race, age, schooling level, and diagnosis of patients seen from 2008 to 2015. Results A total of 760 patients were studied, with a predominance of female (61.3%; p
Keywords: Alzheimer disease; Cognitive dysfunction; Dementia
01/Apr/2016
DOI: 10.1590/S1679-45082016AO3628
ABSTRACT Objective To validate the Pain Assessment Checklist for Seniors with Limited Ability to Communicate – Portuguese in demented elderly and to analyze its measurement properties. Methods We evaluated 50 elderly with dementia, residing in a nursing home and with limited communication ability, when exposed to potentially painful situations. The tool was applied at two different moments. First, two interviewers applied it simultaneously, and the intensity of pain was asked based on the caregiver’s opinion. After 14 days, with no […]
Keywords: Aged, 80 and over; Dementia; Pain; Pain measurement; Validation studies as topic
01/Jan/2015
01/Jan/2015
DOI: 10.1590/S1679-45082015AO3036
Objective To adapt the Pain Assessment in Advanced Dementia (PAINAD) scale to Brazilian Portuguese with respect to semantic equivalence and cultural aspects, and to evaluate the respective psychometric properties (validity, feasibility, clinical utility and inter-rater agreement). Methods Two-stage descriptive, cross-sectional retrospective study involving cultural and semantic validation of the Brazilian Portuguese version of the scale, and investigation of its psychometric properties (validity, reliability and clinical utility). The sample consisted of 63 inpatients presenting with neurological deficits and unable to self-report […]
Keywords: Aged; Dementia; Pain measurement; Scales
01/Oct/2011
DOI: 10.1590/S1679-45082011AO2145
ABSTRACT Objective: To determine the incidence of sleep disorder at a follow-up examination from 1 to 4 years, in demented patients diagnosed at first visit, besides analyzing associated demographic and comorbidities characteristics. Methods: A total of 122 elderly patients aged 60 years or older and diagnosed with dementia (Alzheimer and other) were followed in a reference geriatric center for dementia. The clinical protocols included interviews with patient and caregiver, complete physical examination, laboratory and imaging tests. Criteria for the diagnosis […]
Keywords: Aged; Alzheimer disease; Dementia; Sleep disorders; Sleep initiation and maintenance disorders