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We report the case of a 72-year-old patient with stage III breast cancer who presented with multiple pulmonary nodules incidentally detected on computed tomography (CT). Further investigation using positron emission tomography (PET) revealed additional fluorodeoxyglucose-avid (FDG) chest wall lesions and widespread lymphadenopathy (axillary, retropectoral, supraclavicular, pulmonary hilar, and mediastinal), all highly suggestive of recurrent cancer ( and ).
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Silicone gel migration masquerading as metastatic breast cancer
CarvalhoFM, OliveiraLJC, ShimizuC, BarbosaFG, TestagrossaLA, ManoMS. Silicone gel migration masquerading as metastatic breast cancer. einstein (Sao Paulo). 2025;23:eAI1493. https://doi.org/10.31744/einsteinJournal/2025AI1493
Carvalho,Felipe Magaldi de; Oliveira,Leandro Jonata Carvalho; Shimizu,Carlos; Barbosa,Felipe de Galiza; Testagrossa,Leonardo de Abreu; Mano,Max Senna. Silicone gel migration masquerading as metastatic breast cancer. einstein (Sao Paulo)., v. 23, eAI1493, Mar. 2025. https://doi.org/10.31744/einsteinJournal/2025AI1493
Carvalho,F.M. , Oliveira,L.J.C., Shimizu,C., Barbosa,F.G., Testagrossa,L.A., & Mano,M.S. (2025). Silicone gel migration masquerading as metastatic breast cancer. einstein (Sao Paulo).,23, eAI1493. https://doi.org/10.31744/einsteinJournal/2025AI1493
Carvalho,Felipe Magaldi de and Oliveira,Leandro Jonata Carvalho and Shimizu,Carlos and Barbosa,Felipe de Galiza and Testagrossa,Leonardo de Abreu and Mano,Max Senna. Silicone gel migration masquerading as metastatic breast cancer. einstein (Sao Paulo). [online]. 2025, vol. 23, [cited 2025-09-06], eAI1493. Available from: <https://journal.einstein.br/article/silicone-gel-migration-masquerading-as-metastatic-breast-cancer/>. ISSN 1679-4508. https://doi.org/10.31744/einsteinJournal/2025AI1493
Figure 4.
A high-power view of a microscopic image from a pulmonary biopsy showing macrophages with clear, retractile, nonpolarizable material within cytoplasmic vacuoles (HE; 53.6 ×), characteristic of tissue silicone infiltration
A high-power view of a microscopic image from a pulmonary biopsy showing macrophages with clear, retractile, nonpolarizable material within cytoplasmic vacuoles (HE; 53.6 ×), characteristic of tissue silicone infiltration