The journal einstein (São Paulo) – e-ISSN 2317-6385 is dedicated to dissemination of high-quality scientific content that advances our understanding of human disease with the goal of improving prevention, care, diagnostics and treatment of patients globally.
We report a case of a 61-years-old woman in remission of psoriasis for 20 years. She presented recurrence of psoriasis in the form of plaques few days after taking L-methylfolate 15mg/day. The L-methylfolate was prescribed as an adjuvant for the treatment of depression in a patient with the methylenetetrahydrofolate reductase gene polymorphism (MTHFR).
L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse?
PitliukR, FucciTPPCS. L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse?. Einstein (Sao Paulo). 2020;18:eRC5522. https://doi.org/10.31744/einstein_journal/2020RC5522
Pitliuk,Rubens; Fucci,Tatyanny Paula Pinto da Costa Santos. L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse?. Einstein (Sao Paulo)., v. 18, eRC5522, Nov. 2020. https://doi.org/10.31744/einstein_journal/2020RC5522
Pitliuk,R., & Fucci,T.P.P.C.S. (2020). L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse?. Einstein (Sao Paulo).,18, eRC5522. https://doi.org/10.31744/einstein_journal/2020RC5522
Pitliuk,Rubens and Fucci,Tatyanny Paula Pinto da Costa Santos. L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse?. Einstein (Sao Paulo). [online]. 2020, vol. 18, [cited 2025-09-06], eRC5522. Available from: <https://journal.einstein.br/article/l-methylfolate-a-new-option-in-psychiatric-treatment-would-it-be-linked-to-psoriasis-relapse/>. ISSN 1679-4508. https://doi.org/10.31744/einstein_journal/2020RC5522
Figure 5
Risk of bias assessment of non-RCTs using the ROBINS-I tool
Non-RCT, nonrandomized controlled trial; ROBINS-I, Risk of Bias in Non-Randomized Studies-of Interventions