The journal einstein (São Paulo) – e-ISSN 2317-6385 is dedicated to dissemination of high-quality scientific content that advances our understanding of human disease with the goal of improving prevention, care, diagnostics and treatment of patients globally.
The infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the host cells occurs by interaction of cleaved viral protein spike with the receptors of angiotensin-converting enzyme 2 (ACE2) and of transmembrane serine protease 2 (TMPRSS2). The presence of ACE2 and TMPRSS2 in the salivary glands make them a reservoir for SARS-CoV-2, leading to cell endocytosis and the viral replication cycle. This knowledge is relevant to better understand and develop strategies to mitigate contamination by droplets.()
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Importance of oral health care in times of COVID-19
VilhenaFV, OrcinaBF, ReiaVCB, ZangrandoMR, OliveiraRC, SantosPSS. Importance of oral health care in times of COVID-19. Einstein (Sao Paulo). 2021;19:eCE6706. https://doi.org/10.31744/einstein_journal/2021CE6706
Vilhena,Fabiano Vieira; Orcina,Bernardo da Fonseca; Reia,Verônica Caroline Brito; Zangrando,Mariana Ragghianti; Oliveira,Rodrigo Cardoso de; Santos,Paulo Sérgio da Silva. Importance of oral health care in times of COVID-19. Einstein (Sao Paulo)., v. 19, eCE6706, Dec. 2021. https://doi.org/10.31744/einstein_journal/2021CE6706
Vilhena,F.V., Orcina,B.F., Reia,V.C.B., Zangrando,M.R., Oliveira,R.C. , & Santos,P.S.S. (2021). Importance of oral health care in times of COVID-19. Einstein (Sao Paulo).,19, eCE6706. https://doi.org/10.31744/einstein_journal/2021CE6706
Vilhena,Fabiano Vieira and Orcina,Bernardo da Fonseca and Reia,Verônica Caroline Brito and Zangrando,Mariana Ragghianti and Oliveira,Rodrigo Cardoso de and Santos,Paulo Sérgio da Silva. Importance of oral health care in times of COVID-19. Einstein (Sao Paulo). [online]. 2021, vol. 19, [cited 2025-09-08], eCE6706. Available from: <https://journal.einstein.br/article/importance-of-oral-health-care-in-times-of-covid-19/>. ISSN 1679-4508. https://doi.org/10.31744/einstein_journal/2021CE6706
Figure 5
Risk of bias assessment of non-RCTs using the ROBINS-I tool
Non-RCT, nonrandomized controlled trial; ROBINS-I, Risk of Bias in Non-Randomized Studies-of Interventions