The journal einstein (São Paulo) – e-ISSN 2317-6385 is dedicated to dissemination of high-quality scientific content that advances our understanding of human disease with the goal of improving prevention, care, diagnostics and treatment of patients globally.
This case report describes neurotoxicity in an older patient on cefepime 2 g twice a day. The 81-year-old male patient developed non-convulsive status epilepticus during cefepime treatment with 1 g twice a day. There was recovery 30 days after discontinuation of cefepime.
Cefepime-induced encephalopathy in patient without renal failure
CoelhoFMS, BernsteinM, YokotaPKO, CoelhoRME, WachembergM, SampaioLPB, CabocloLO. Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo). 2010;8(3):358-60. https://doi.org/10.1590/S1679-45082010RC1121
Coelho,Fernando Morgadinho Santos; Bernstein,Maurício; Yokota,Paula Kiyomi Onaga; Coelho,Rosilene Motta Elias; Wachemberg,Marcelo; Sampaio,Letícia Pereira de Brito; Caboclo,Luis Otávio. Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo)., v. 8, n. 3, p. 358-360, Jul. 2010. https://doi.org/10.1590/S1679-45082010RC1121
Coelho,F.M.S., Bernstein,M., Yokota,P.K.O., Coelho,R.M.E., Wachemberg,M., Sampaio,L.P.B., & Caboclo,L.O. (2010). Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo).,8(3), 358-360. https://doi.org/10.1590/S1679-45082010RC1121
Coelho,Fernando Morgadinho Santos and Bernstein,Maurício and Yokota,Paula Kiyomi Onaga and Coelho,Rosilene Motta Elias and Wachemberg,Marcelo and Sampaio,Letícia Pereira de Brito and Caboclo,Luis Otávio. Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo). [online]. 2010, vol. 8, n. 3, [cited 2025-09-05], pp.358-360. Available from: <https://journal.einstein.br/article/cefepime-induced-encephalopathy-in-patient-without-renal-failure/>. ISSN 1679-4508. https://doi.org/10.1590/S1679-45082010RC1121
Figure 3
Relationship between creatinine and clearance (by Cockroft-Gault formula)
