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This case report describes neurotoxicity in an older patient on cefepime 2 g twice a day. The 81-year-old male patient developed non-convulsive status epilepticus during cefepime treatment with 1 g twice a day. There was recovery 30 days after discontinuation of cefepime.
Cefepime-induced encephalopathy in patient without renal failure
CoelhoFMS, BernsteinM, YokotaPKO, CoelhoRME, WachembergM, SampaioLPB, CabocloLO. Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo). 2010;8(3):358-60. https://doi.org/10.1590/S1679-45082010RC1121
Coelho,Fernando Morgadinho Santos; Bernstein,Maurício; Yokota,Paula Kiyomi Onaga; Coelho,Rosilene Motta Elias; Wachemberg,Marcelo; Sampaio,Letícia Pereira de Brito; Caboclo,Luis Otávio. Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo)., v. 8, n. 3, p. 358-360, Jul. 2010. https://doi.org/10.1590/S1679-45082010RC1121
Coelho,F.M.S., Bernstein,M., Yokota,P.K.O., Coelho,R.M.E., Wachemberg,M., Sampaio,L.P.B., & Caboclo,L.O. (2010). Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo).,8(3), 358-360. https://doi.org/10.1590/S1679-45082010RC1121
Coelho,Fernando Morgadinho Santos and Bernstein,Maurício and Yokota,Paula Kiyomi Onaga and Coelho,Rosilene Motta Elias and Wachemberg,Marcelo and Sampaio,Letícia Pereira de Brito and Caboclo,Luis Otávio. Cefepime-induced encephalopathy in patient without renal failure. Einstein (Sao Paulo). [online]. 2010, vol. 8, n. 3, [cited 2025-09-27], pp.358-360. Available from: <https://journal.einstein.br/article/cefepime-induced-encephalopathy-in-patient-without-renal-failure/>. ISSN 1679-4508. https://doi.org/10.1590/S1679-45082010RC1121
Figure 3
Relationship between creatinine and clearance (by Cockroft-Gault formula)
