2 results
22/Sep/2025
DOI: 10.31744/einstein_journal/2025AO1421
Highlights ■ Higher miR-23a levels in patients with premature ovarian insufficiency vs. normovulatory women. ■ Lower miR-146a levels in patients with premature ovarian insufficiency vs. normovulatory women. ■ Novel biomarkers for early diagnosis and monitoring of premature ovarian insufficiency. ■ Potential biomarkers to therapeutic targets for premature ovarian insufficiency. ABSTRACT Objective: This study aimed to analyze the expression profiles of miR-23a and miR-146a in women with premature ovarian insufficiency and to evaluate their value as biomarkers of the disease for […]
Keywords: Autoimmunity; Biomarkers; Inflammation; MicroRNAs; Peripheral blood; Primary ovarian insufficiency
31/Oct/2024
DOI: 10.31744/einstein_journal/2024AO0712
Highlights ■ The MCM8 gene is involved in homologous recombination, acting in the ovarian follicles during meiosis II. ■ To the best of our knowledge, this is the first study to report the presence of this variant in a Brazilian woman. ■ The rs138761187 variant had a low incidence; further studies with a larger sample size or focusing on variants at other gene positions may provide insight into the genetic causes of premature ovarian insufficiency. ABSTRACT Introduction: The MCM8 gene […]
Keywords: Minichromosome maintenance proteins; Ovarian diseases; Primary ovarian insufficiency