INTRODUCTION Premature ovarian insufficiency (POI) is a clinical syndrome characterized by oligo/amenorrhea observed in women before the age of 40 years, lasting at least 4 months, with elevated follicle-stimulating hormone (FSH) levels.() Its diagnosis is confirmed by two serum measurements conducted at least 1 month apart that show high FSH levels (>25IU/L) and low estradiol levels.() The condition is caused by varying factors, including genetic, immunological, or metabolic factors; iatrogenic intervention; and environmental toxins. The reason is idiopathic in 90% […]

Highlights ■ The MCM8 gene is involved in homologous recombination, acting in the ovarian follicles during meiosis II. ■ To the best of our knowledge, this is the first study to report the presence of this variant in a Brazilian woman. ■ The rs138761187 variant had a low incidence; further studies with a larger sample size or focusing on variants at other gene positions may provide insight into the genetic causes of premature ovarian insufficiency. ABSTRACT Introduction: The MCM8 gene […]