Highlights ■ HPV+ is associated with improved overall survival in oropharyngeal cancer ■ HPV+ tumors tend to recur earlier than HPV- tumors. ■ Metastasis is a key prognostic factor for mortality and recurrence regardless of HPV status. ■ Smoking and alcohol consumption reduce the favorable prognosis of HPV+. ABSTRACT Objective: To analyze the overall and disease-free survival of patients with oropharyngeal squamous cell carcinoma. Methods: Sociodemographic and clinical data, HPV status, and alcohol/tobacco consumption were assessed among patients treated at […]