Highlights ■ Typical perifissural nodules remain radiologically stable with no metastatic potential. ■ Only two nodules progressed to metastasis (one atypical perifissural nodule and one non-perifissural nodule). ■ Atypical and non-perifissural nodules require closer follow-up. ■ Annual growth rate was a strong marker of malignancy. ABSTRACT Objective: To evaluate whether pulmonary nodules adjacent to fissures, particularly perifissural nodules detected on chest computed tomography in patients with hepatocellular carcinoma, can be reliably classified as benign based on their radiological characteristics. Methods: […]