2 results
10/Sep/2024
DOI: 10.31744/einstein_journal/2024AO0412
Highlights Klotho controls cellular pathways and is a key factor in senescence and longevity. FGF-23 regulates phosphorus and vitamin D metabolism in a Klotho-dependent manner. Bone formation in Klotho-deficient mice decreased similar to that in aged humans. Renal function and lumbar spine bone mineral density were related to Klotho and FGF-23, respectively. ABSTRACT Objective: To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals. Methods: A total of 55 individuals […]
Keywords: Aged; Biomarkers; Bone density; FGF-23 protein; Human; Klotho protein; Longevity
01/Jul/2011
DOI: 10.1590/S1679-45082011RW1953
ABSTRACT The association between total mortality, lipoproteinS, and inflammatory markers, and their implications with aging and longevity are often controversial. Among the most often studied markers are low HDL cholesterol and high C-reactive protein. Particularly in octogenarians, it is expected that the impact of the inclusion of HDL cholesterol and C-reactive protein will improve the stratification of absolute cardiovascular risk. In the present study, we performed a literature review in PubMed about the relation between HDL cholesterol, inflammation and longevity. […]
Keywords: C-reactive protein; Cardiovascular system; Cholesterol, HDL; Lipids; Lipoproteins, HDL; Longevity; Mortality